This article begins with a review of gastric emptying, small intestine transit, and colonic transit
of drug delivery systems with special attention paid to the different physiological processes …

Recent studies of genomic variation associated with autism have suggested the existence
of extreme heterogeneity. Large-scale transcriptomics should complement these results to …

SLC12A3 encodes the thiazide-sensitive sodium chloride cotransporter (NCC), which is
primarily expressed in the kidney, but also in intestine and bone. In the kidney, NCC is located …

Mitochondrial function is altered with age and variants in mitochondrial DNA (mtDNA)
modulate risk for several age-related disease states. However, the association of mtDNA copy …

Optimized floating (F) and non‐floating (NF) hydrophilic matrix capsules have been
characterized in vitro with regard to their buoyancy or non—buoyancy capabilities and their …

Peroral floating dosage forms have up to now been used and prescribed without having
achieved any determination of their real floating capabilities versus time. Using a novel in vitro …

Physical and thermal properties of Compritol ® and Precirol ® as potential lipophilic binders
in melt pelletisation process for the preparation of sustained-release matrix pellets were …

Importance Mitochondrial dysfunction is a core component of the aging process and may
play a key role in atherosclerotic cardiovascular disease. Mitochondrial DNA copy number (…

Empty or nifedipine-loaded biodegradable poly(dl-lactide-co-glycolide) microspheres were
prepared by the solvent evaporation method. Spherical microparticles of different size …

Previous published works have shown that hydrodynamically balanced systems (HBS) — ie
sustained release oral dosage forms with a specific gravity lower than 1 and remaining …