Desmoid tumors are fibroblastic/myofibroblastic proliferations. Previous studies reported that
CTNNB1 mutations were detected in 84% and that mutations of the APC gene were found …

Objective Epidemiological and clinical data indicate that patients suffering from IBD with
long-standing colitis display a higher risk to develop colorectal high-grade dysplasia. Whereas …

After pancreatic islet transplantation, insufficient blood supply is responsible for the loss of
islet viability. The aim of our study was: 1) to determine the influence of vascular endothelial …

Laminins represent a growing family of glycoproteins constituting the basement membrane.
They are known to direct many biological processes. With respect to carcinogenesis, …

Laminins (LM), basement membrane molecules and mediators of epithelial-stromal
communication, are crucial in tissue homeostasis. Inflammatory Bowel Diseases (IBD) are …

Transplantation of pancreatic islets is proposed as a treatment for type 1 diabetes, but
insufficient blood supply can cause the loss of viable grafted islets. In the present study, we …

Background Information Tumor stroma remodeling is a key feature of malignant tumors and
can promote cancer progression. Laminins are major constituents of basement membranes …

Matrix metalloproteinase 2 (MMP2) activity is associated with the aggressiveness of human
cancers. Therefore, the mechanisms regulating its activation are of great interest for a better …

Gene transfer with adenoviral vectors is an attractive approach for the treatment of
atherosclerosis and restenosis. However, because expression of a therapeutic gene in nontarget …

Large block macrosectioning of segmental excision specimens for breast cancer, and
especially ductal carcinoma in situ, provides detailed information regarding size of the lesions, …