Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA

LD Chiaradia, A Mascarello, M Purificação… - Bioorganic & medicinal …, 2008 - Elsevier
In the search for lead compounds for new drugs for tuberculosis, the activity of 38 synthetic
chalcones were assayed for their potential inhibitory action towards a protein tyrosine …

[HTML][HTML] Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth

A Mascarello, LD Chiaradia, J Vernal, A Villarino… - Bioorganic & medicinal …, 2010 - Elsevier
Tuberculosis (TB) is a major cause of morbidity and mortality throughout the world, and it is
estimated that one-third of the world’s population is infected with Mycobacterium tuberculosis…

Strategies for disease prevention and health promotion in urban areas: the Erice 50 Charter

…, V Marchese, A Marzella, A Mascarello… - Annali di Igiene …, 2017 - re.public.polimi.it
The Erice 50 Charter titled “Strategies for Diseases Prevention and Health Promotion in
Urban Areas” was unanimously approved at the conclusion of the 50th Residential Course “…

Activity of novel quinoxaline-derived chalcones on in vitro glioma cell proliferation

TR Mielcke, A Mascarello, E Filippi-Chiela… - European Journal of …, 2012 - Elsevier
Gliomas are the most common and devastating tumors of the central nervous system (CNS).
Many pieces of evidence point out the relevance of natural compounds for cancer therapy …

[HTML][HTML] Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (PtpB) Inhibitors from Natural Products

A Mascarello, M Mori, LD Chiaradia-Delatorre… - PloS one, 2013 - journals.plos.org
Protein tyrosine phosphatase B (PtpB) is one of the virulence factors secreted into the host
cell by Mycobacterium tuberculosis. PtpB attenuates host immune defenses by interfering with …

Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus

…, F Delle Monache, LD Chiaradia, A Mascarello… - Bioorganic & medicinal …, 2012 - Elsevier
The increase in antibiotic resistance due to multiple factors has encouraged the search for
new compounds which are active against multidrug-resistant pathogens. In this context, …

Synthetic strategies toward SGLT2 inhibitors

AR Aguillon, A Mascarello, ND Segretti… - … Process Research & …, 2018 - ACS Publications
Gliflozins are an important class of prescription drugs used to treat type II diabetes. They
reduce blood sugar levels by targeting the sodium-glucose transport protein 2 (SGLT2) and …

[HTML][HTML] Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia

FTG de Sousa Cardozo, CM Camelini, A Mascarello… - Antiviral research, 2011 - Elsevier
Sulfated polysaccharides are good candidates for drug discovery in the treatment of herpetic
infections. Agaricus brasiliensis (syn A. subrufescens, A. blazei) is a Basidiomycete fungus …

Mechanism of action of novel glibenclamide derivatives on potassium and calcium channels for insulin secretion

…, C Pires Mendes, A Mascarello… - Current Drug …, 2017 - ingentaconnect.com
Glibenclamide is widely used and remains a cornerstone and an effective antihyperglycemic
drug. After the casual discovery of its hypoglycemic potential, this compound was …

Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B

A Mascarello, ACO Menegatti, A Calcaterra… - European journal of …, 2018 - Elsevier
Mycobacterium tuberculosis (Mtb) protein tyrosine phosphatases A and B (PtpA and PtpB)
have been recognized as potential molecular targets for the development of new therapeutic …