Invasive pancreatic ductal adenocarcinoma is an almost uniformly fatal disease. Several
distinct noninvasive precursor lesions can give rise to invasive adenocarcinoma of the pancreas…

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the Western world with limited therapeutic options and dismal long-term survival. The …

The past two decades have witnessed an explosion in our understanding of pancreatic
cancer, and it is now clear that pancreatic cancer is a disease of inherited (germ-line) and …

Doxorubicin (DXR) commonly used in cancer therapy produces undesirable side effects
such as cardiotoxicity. To minimize these, attempts have been made to couple the drug with …

Naqvi S, Samim M, Abdin M, et al. Int J Nanomedicine. 2010;5:983–989. The Editor and
Publisher of the International Journal of Nanomedicine wish to retract the published article. …

Pancreatic cancer remains one of the most lethal of malignancies and a major health burden.
We performed whole-genome sequencing and copy number variation (CNV) analysis of …

There are currently few therapeutic options for patients with pancreatic cancer, and new
insights into the pathogenesis of this lethal disease are urgently needed. Toward this end, we …

Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently
mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/…

To evaluate the role of oncogenic RAS mutations in pancreatic tumorigenesis, we directed
endogenous expression of KRAS G12D to progenitor cells of the mouse pancreas. We find …

The p53 tumor suppressor protein is a critical regulator of the cellular response to cancer-initiating
insults such as genotoxic stress. In this report, we demonstrate that microRNAs (…