User profiles for A. Loewer
Alexander LoewerProfessor, Technical University Darmstadt Verified email at mdc-berlin.de Cited by 12579 |
The ups and downs of p53: understanding protein dynamics in single cells
E Batchelor, A Loewer, G Lahav - Nature Reviews Cancer, 2009 - nature.com
Cells living in a complex environment must constantly detect, process and appropriately
respond to changing signals. Therefore, all cellular information processing is dynamic in nature. …
respond to changing signals. Therefore, all cellular information processing is dynamic in nature. …
p53 dynamics control cell fate
Cells transmit information through molecular signals that often show complex dynamical
patterns. The dynamic behavior of the tumor suppressor p53 varies depending on the stimulus; …
patterns. The dynamic behavior of the tumor suppressor p53 varies depending on the stimulus; …
Circular RNAs are a large class of animal RNAs with regulatory potency
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function.
To explore circRNAs systematically, we sequenced and computationally analysed human, …
To explore circRNAs systematically, we sequenced and computationally analysed human, …
Homo‐and heterodimerization of APP family members promotes intercellular adhesion
… Lower levels of APLP2ΔCT interaction are due to lower expression levels of this construct.
(C) Heterointeraction of APP, APLP1, and APLP2 with different deletion constructs in COS7 …
(C) Heterointeraction of APP, APLP1, and APLP2 with different deletion constructs in COS7 …
We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells
A Loewer, G Lahav - Current opinion in genetics & development, 2011 - Elsevier
The human body is formed by trillions of individual cells. These cells work together with
remarkable precision, first forming an adult organism out of a single fertilized egg, and then …
remarkable precision, first forming an adult organism out of a single fertilized egg, and then …
[HTML][HTML] Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells
The tumor suppressor p53 is activated by stress and leads to cellular outcomes such as
apoptosis and cell-cycle arrest. Its activation must be highly sensitive to ensure that cells react …
apoptosis and cell-cycle arrest. Its activation must be highly sensitive to ensure that cells react …
Stimulus‐dependent dynamics of p53 in single cells
E Batchelor, A Loewer, C Mock… - Molecular systems biology, 2011 - embopress.org
Many biological networks respond to various inputs through a common signaling molecule
that triggers distinct cellular outcomes. One potential mechanism for achieving specific input–…
that triggers distinct cellular outcomes. One potential mechanism for achieving specific input–…
[PDF][PDF] Cell-to-cell variation in p53 dynamics leads to fractional killing
Many chemotherapeutic drugs kill only a fraction of cancer cells, limiting their efficacy. We
used live-cell imaging to investigate the role of p53 dynamics in fractional killing of colon …
used live-cell imaging to investigate the role of p53 dynamics in fractional killing of colon …
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction
JD Orth, A Loewer, G Lahav… - Molecular biology of the …, 2012 - Am Soc Cell Biol
Mitotic arrest induced by antimitotic drugs can cause apoptosis or p53-dependent cell cycle
arrest. It can also cause DNA damage, but the relationship between these events has been …
arrest. It can also cause DNA damage, but the relationship between these events has been …
Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells
Levels of residual structure in disordered interaction domains determine in vitro binding
affinities, but whether they exert similar roles in cells is not known. Here, we show that increasing …
affinities, but whether they exert similar roles in cells is not known. Here, we show that increasing …