Cells living in a complex environment must constantly detect, process and appropriately
respond to changing signals. Therefore, all cellular information processing is dynamic in nature. …

Cells transmit information through molecular signals that often show complex dynamical
patterns. The dynamic behavior of the tumor suppressor p53 varies depending on the stimulus; …

Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function.
To explore circRNAs systematically, we sequenced and computationally analysed human, …

… Lower levels of APLP2ΔCT interaction are due to lower expression levels of this construct.
(C) Heterointeraction of APP, APLP1, and APLP2 with different deletion constructs in COS7 …

The human body is formed by trillions of individual cells. These cells work together with
remarkable precision, first forming an adult organism out of a single fertilized egg, and then …

The tumor suppressor p53 is activated by stress and leads to cellular outcomes such as
apoptosis and cell-cycle arrest. Its activation must be highly sensitive to ensure that cells react …

Many biological networks respond to various inputs through a common signaling molecule
that triggers distinct cellular outcomes. One potential mechanism for achieving specific input–…

Many chemotherapeutic drugs kill only a fraction of cancer cells, limiting their efficacy. We
used live-cell imaging to investigate the role of p53 dynamics in fractional killing of colon …

Mitotic arrest induced by antimitotic drugs can cause apoptosis or p53-dependent cell cycle
arrest. It can also cause DNA damage, but the relationship between these events has been …

Levels of residual structure in disordered interaction domains determine in vitro binding
affinities, but whether they exert similar roles in cells is not known. Here, we show that increasing …