The microbiota of the human gut is gaining broad attention owing to its association with a
wide range of diseases, ranging from metabolic disorders (eg obesity and type 2 diabetes) to …

The advent of microRNA has potentially uncovered a new level of complexity to be considered
for every biological process. Through the modulation of transcription and translation, …

Regulatory T (T Reg ) cells constitute an essential counterbalance to adaptive immune
responses. Failure to maintain appropriate T Reg cell numbers or function leads to autoimmune, …

The woodland strawberry, Fragaria vesca (2n = 2x = 14), is a versatile experimental plant
system. This diminutive herbaceous perennial has a small genome (240 Mb), is amenable to …

Follicular helper (T FH ) cells provide crucial signals to germinal center B cells undergoing
somatic hypermutation and selection that results in affinity maturation. Tight control of T FH …

Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of
stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human lung …

Eucalypts are the world’s most widely planted hardwood trees. Their outstanding diversity,
adaptability and growth have made them a global renewable resource of fibre and energy. …

Autoimmune polyendocrinopathy syndrome type 1 is a recessive Mendelian disorder
resulting from mutations in a novel gene, AIRE, and is characterized by a spectrum of organ-…

In less than a decade, the polymerase chain reaction (PCR) has evolved into the common
denominator of molecular biology for nucleic acid research. The most important impact of PCR …

Despite the importance of thymic stromal cells to T-cell development, relatively little is known
about their biology. Here, we use single-cell analysis of stromal cells to analyze extensive …