User profiles for A. Leache

Andrew Leach

- Verified email at ebi.ac.uk - Cited by 31490

Adam Leaché

- Verified email at uw.edu - Cited by 9745

Allison Leach

- Verified email at unh.edu - Cited by 7232

The utility of single nucleotide polymorphism (SNP) data in phylogenetics

AD Leaché, JR Oaks - Annual Review of Ecology, Evolution …, 2017 - annualreviews.org
Resolving the genealogy of life—the phylogenetic relationships that describe the evolutionary
history of species—remains one of the great challenges of systematic biology. The recent …

The global nitrogen cycle in the twenty-first century

…, JN Galloway, P Vitousek, A Leach… - … of the Royal …, 2013 - royalsocietypublishing.org
Global nitrogen fixation contributes 413 Tg of reactive nitrogen (N r ) to terrestrial and marine
ecosystems annually of which anthropogenic activities are responsible for half, 210 Tg N. …

An analysis of the attrition of drug candidates from four major pharmaceutical companies

MJ Waring, J Arrowsmith, AR Leach… - Nature reviews Drug …, 2015 - nature.com
The pharmaceutical industry remains under huge pressure to address the high attrition rates
in drug development. Attempts to reduce the number of efficacy- and safety-related failures …

Bayesian species delimitation in West African forest geckos (Hemidactylus fasciatus)

AD Leaché, MK Fujita - … of the Royal Society B: Biological …, 2010 - royalsocietypublishing.org
Genealogical data are an important source of evidence for delimiting species, yet few statistical
methods are available for calculating the probabilities associated with different species …

Species delimitation using genome-wide SNP data

AD Leaché, MK Fujita, VN Minin… - Systematic …, 2014 - academic.oup.com
The multispecies coalescent has provided important progress for evolutionary inferences,
including increasing the statistical rigor and objectivity of comparisons among competing …

Short tree, long tree, right tree, wrong tree: new acquisition bias corrections for inferring SNP phylogenies

AD Leaché, BL Banbury, J Felsenstein… - Systematic …, 2015 - academic.oup.com
Single nucleotide polymorphisms (SNPs) are useful markers for phylogenetic studies owing
in part to their ubiquity throughout the genome and ease of collection. Restriction site …

[HTML][HTML] Late Cretaceous origin of the rice tribe provides evidence for early diversification in Poaceae

V Prasad, CAE Strömberg, AD Leaché… - Nature …, 2011 - nature.com
Rice and its relatives are a focal point in agricultural and evolutionary science, but a paucity
of fossils has obscured their deep-time history. Previously described cuticles with silica …

Molecular Systematics of the Eastern Fence Lizard (Sceloporus undulatus): A Comparison of Parsimony, Likelihood, and Bayesian Approaches

AD Leaché, TW Reeder - Systematic biology, 2002 - academic.oup.com
Phylogenetic analysis of large datasets using complex nucleotide substitution models under
a maximum likelihood framework can be computationally infeasible, especially when …

Phylogenomics of phrynosomatid lizards: conflicting signals from sequence capture versus restriction site associated DNA sequencing

AD Leache, AS Chavez, LN Jones… - Genome biology and …, 2015 - academic.oup.com
Sequence capture and restriction site associated DNA sequencing (RADseq) are popular
methods for obtaining large numbers of loci for phylogenetic analysis. These methods are …

The ChEMBL database in 2017

…, G Papadatos, I Smit, AR Leach - Nucleic acids …, 2017 - academic.oup.com
ChEMBL is an open large-scale bioactivity database ( https://www.ebi.ac.uk/chembl ), previously
described in the 2012 and 2014 Nucleic Acids Research Database Issues. Since then, …