The nucleolus is a distinct subnuclear compartment that was first observed more than 200
years ago. Nucleoli assemble around the tandemly repeated ribosomal DNA gene clusters …

Current evidence suggests that the nucleus has a distinct substructure, albeit one that is
dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited …

Cells typically respond quickly to stress, altering their metabolism to compensate. In mammalian
cells, stress signaling usually leads to either cell-cycle arrest or apoptosis, depending …

The nucleolus is a key organelle that coordinates the synthesis and assembly of ribosomal
subunits and forms in the nucleus around the repeated ribosomal gene clusters. Because the …

Background: The nucleolus is a subnuclear organelle containing the ribosomal RNA gene
clusters and ribosome biogenesis factors. Recent studies suggest it may also have roles in …

In a previous proteomic study of the human spliceosome, we identified 42 spliceosome-associated
factors, including 19 novel ones. Using enhanced mass spectrometric tools and …

Acute promyelocytic leukemia (APL) is characterized by a specific t (l5; 17) translocation that
fuses the retinoic acid receptor a (RAFta) to a novel gene product, PML. The involvement of …

… We thank members of the Spector and Lamond groups for helpful comments. Angus Lamond
is a Wellcome Trust Principal Research Fellow. David L. Spector is funded by NIGMS/NIH …

BACKGROUND: Resilience, the ability to adapt positively to adversity, may be an important
factor in successful aging. However, the assessment and correlates of resilience in elderly …

Many important cell mechanisms are carried out and regulated by multi-protein complexes,
for example, transcription and RNA processing machinery, receptor complexes and …