Mesenchymal stem cells in cartilage repair: state of the art and methods to monitor cell growth, differentiation and cartilage regeneration

…, W Grill, B Fuchs, JA Kas, A Krinner… - Current medicinal …, 2010 - ingentaconnect.com
Degenerative joint diseases caused by rheumatism, joint dysplasia or traumata are
particularly widespread in countries with high life expectation. Although there is no absolutely …

Impact of oxygen environment on mesenchymal stem cell expansion and chondrogenic differentiation

A Krinner, M Zscharnack, A Bader, D Drasdo… - Cell …, 2009 - Wiley Online Library
Introduction: In vitro expansion and differentiation of mesenchymal stem cells (MSC) rely on
specific environmental conditions, and investigations have demonstrated that one crucial …

In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells

…, MK Scott, N Scherf, A Krinner… - Blood, The Journal …, 2014 - ashpublications.org
Hematopoietic stem cells (HSCs) maintain the turnover of mature blood cells during steady
state and in response to systemic perturbations such as infections. Their function critically …

[HTML][HTML] Merging concepts-coupling an agent-based model of hematopoietic stem cells with an ODE model of granulopoiesis

A Krinner, I Roeder, M Loeffler, M Scholz - BMC systems biology, 2013 - Springer
Background Hematopoiesis is a complex process involving different cell types and feedback
mechanisms mediated by cytokines. This complexity stimulated various models with …

[HTML][HTML] Individual fates of mesenchymal stem cells in vitro

A Krinner, M Hoffmann, M Loeffler, D Drasdo… - BMC systems …, 2010 - Springer
Background In vitro cultivated stem cell populations are in general heterogeneous with
respect to their expression of differentiation markers. In hematopoietic progenitor populations, …

[HTML][HTML] Full dynamic ball bearing model with elastic outer ring for high speed applications

C Wagner, A Krinner, T Thümmel, D Rixen - Lubricants, 2017 - mdpi.com
Ball bearings are commonly used in high speed turbomachinery and have a critical influence
on the rotordynamic behavior. Therefore, a simulation model of the bearing to predict the …

Quantification and modeling of stem cell–niche interaction

A Krinner, I Roeder - A Systems Biology Approach to Blood, 2014 - Springer
Adult stem cells persist lifelong in the organism, where they are responsible for tissue homeostasis
and repair. It is commonly assumed that their maintenance and function are facilitated …

Bistable epigenetic states explain age-dependent decline in mesenchymal stem cell heterogeneity

Z Hamidouche, K Rother, J Przybilla, A Krinner… - Stem Cells, 2017 - academic.oup.com
The molecular mechanisms by which heterogeneity, a major characteristic of stem cells, is
achieved are yet unclear. We here study the expression of the membrane stem cell antigen-1 (…

Single cell phenotyping reveals heterogeneity among hematopoietic stem cells following infection

…, R Khorshed, NM Rashidi, N Scherf, A Krinner… - Stem Cells, 2017 - academic.oup.com
The hematopoietic stem cell (HSC) niche provides essential microenvironmental cues for
the production and maintenance of HSCs within the bone marrow. During inflammation, …

Plasma‐free vs deconjugated metanephrines for diagnosis of phaeochromocytoma

…, JWM Lenders, K Pacak, A Krinner… - Clinical …, 2013 - Wiley Online Library
Background The diagnosis of phaeochromocytoma is commonly performed by the
measurements of plasma‐free normetanephrine and metanephrine. Plasma‐deconjugated …