User profiles for A. Krachler
Anne Marie KrachlerAssociate Professor, Microbiology and Molecular Genetics, UT Health Science Center … Verified email at uth.tmc.edu Cited by 2895 |
Mechanisms of outer membrane vesicle entry into host cells
EJ O'donoghue, AM Krachler - Cellular microbiology, 2016 - Wiley Online Library
Bacterial outer membrane vesicles (OMVs) are nano‐sized compartments consisting of a
lipid bilayer that encapsulates periplasm‐derived, luminal content. OMVs, which pinch off of …
lipid bilayer that encapsulates periplasm‐derived, luminal content. OMVs, which pinch off of …
Targeting the bacteria–host interface: strategies in anti-adhesion therapy
AM Krachler, K Orth - Virulence, 2013 - Taylor & Francis
Bacterial infections are a major cause of morbidity and mortality worldwide and are increasingly
problematic to treat due to the rise in antibiotic-resistant strains. It becomes more and …
problematic to treat due to the rise in antibiotic-resistant strains. It becomes more and …
Manipulation of kinase signaling by bacterial pathogens
AM Krachler, AR Woolery, K Orth - Journal of Cell Biology, 2011 - rupress.org
Bacterial pathogens use effector proteins to manipulate their hosts to propagate infection.
These effectors divert host cell signaling pathways to the benefit of the pathogen and …
These effectors divert host cell signaling pathways to the benefit of the pathogen and …
Outer membrane adhesion factor multivalent adhesion molecule 7 initiates host cell binding during infection by gram-negative pathogens
AM Krachler, H Ham, K Orth - Proceedings of the National …, 2011 - National Acad Sciences
The initial binding of bacteria to host cells is crucial to the delivery of virulence factors and
thus is a key determinant of the pathogen's success. We report a multivalent adhesion …
thus is a key determinant of the pathogen's success. We report a multivalent adhesion …
[PDF][PDF] Type III effector VopC mediates invasion for Vibrio species
L Zhang, AM Krachler, CA Broberg, Y Li, H Mirzaei… - Cell reports, 2012 - cell.com
Vibrio spp. are associated with infections caused by contaminated food and water. A type III
secretion system (T3SS2) is a shared feature of all clinical isolates of V. parahaemolyticus …
secretion system (T3SS2) is a shared feature of all clinical isolates of V. parahaemolyticus …
Outer membrane vesicle-host cell interactions
…, NM O'Brien-Simpson, AM Krachler - Microbiology …, 2019 - Am Soc Microbiol
Outer membrane vesicles (OMVs) are nanosized proteoliposomes derived from the outer
membrane of Gram-negative bacteria. They are ubiquitously produced both in culture and …
membrane of Gram-negative bacteria. They are ubiquitously produced both in culture and …
Against the tide: the role of bacterial adhesion in host colonization
DH Stones, AM Krachler - Biochemical Society Transactions, 2016 - portlandpress.com
Evolving under the constant exposure to an abundance of diverse microbial life, the human
body has developed many ways of defining the boundaries between self and non-self. Many …
body has developed many ways of defining the boundaries between self and non-self. Many …
Allosteric β‐propeller signalling in TolB and its manipulation by translocating colicins
…, M Vankemmelbeke, A Sharma, AM Krachler… - The EMBO …, 2009 - embopress.org
The Tol system is a five‐protein assembly parasitized by colicins and bacteriophages that
helps stabilize the Gram‐negative outer membrane (OM). We show that allosteric signalling …
helps stabilize the Gram‐negative outer membrane (OM). We show that allosteric signalling …
[HTML][HTML] Functional characterization of the interaction between bacterial adhesin multivalent adhesion molecule 7 (MAM7) protein and its host cell ligands
AM Krachler, K Orth - Journal of Biological Chemistry, 2011 - ASBMB
The ability of a pathogen to rapidly form a stable interaction with the host cell surface is key
to its success. Bacterial pathogens use a repertoire of virulence factors, but their efficient use …
to its success. Bacterial pathogens use a repertoire of virulence factors, but their efficient use …
[HTML][HTML] Lipopolysaccharide structure impacts the entry kinetics of bacterial outer membrane vesicles into host cells
Outer membrane vesicles are nano-sized microvesicles shed from the outer membrane of
Gram-negative bacteria and play important roles in immune priming and disease pathogenesis…
Gram-negative bacteria and play important roles in immune priming and disease pathogenesis…