User profiles for A. Klimas

Aleksandra Klimas

Carnegie Mellon University
Verified email at andrew.cmu.edu
Cited by 888

Cardiac applications of optogenetics

CM Ambrosi, A Klimas, J Yu, E Entcheva - Progress in biophysics and …, 2014 - Elsevier
In complex multicellular systems, such as the brain or the heart, the ability to selectively
perturb and observe the response of individual components at the cellular level and with …

The organized nonlinear dynamics of the magnetosphere

AJ Klimas, D Vassiliadis, DN Baker… - Journal of Geophysical …, 1996 - Wiley Online Library
The linear prediction filters computed by Bargatze et al. [1985] have resulted in a turning
point in the study of solar wind‐magnetosphere coupling. The evolution of the filters with …

New measure of the dissipation region in collisionless magnetic reconnection

S Zenitani, M Hesse, A Klimas, M Kuznetsova - Physical review letters, 2011 - APS
A new measure to identify a small-scale dissipation region in collisionless magnetic
reconnection is proposed. The energy transfer from the electromagnetic field to plasmas in the …

[HTML][HTML] Multimodal on-axis platform for all-optical electrophysiology with near-infrared probes in human stem-cell-derived cardiomyocytes

A Klimas, G Ortiz, SC Boggess, EW Miller… - Progress in biophysics …, 2020 - Elsevier
Combined optogenetic stimulation and optical imaging permit scalable, contact-free high-throughput
probing of cellular electrophysiology and optimization of stem-cell derived excitable …

[HTML][HTML] OptoDyCE as an automated system for high-throughput all-optical dynamic cardiac electrophysiology

A Klimas, CM Ambrosi, J Yu, JC Williams… - Nature …, 2016 - nature.com
The improvement of preclinical cardiotoxicity testing, discovery of new ion-channel-targeted
drugs, and phenotyping and use of stem cell-derived cardiomyocytes and other biologics all …

Optical control of excitation waves in cardiac tissue

RAB Burton, A Klimas, CM Ambrosi, J Tomek… - Nature …, 2015 - nature.com
In nature, macroscopic excitation waves 1 , 2 are found in a diverse range of settings
including chemical reactions, metal rust, yeast, amoeba and the heart and brain. In the case of …

[HTML][HTML] Computational optogenetics: empirically-derived voltage-and light-sensitive channelrhodopsin-2 model

JC Williams, J Xu, Z Lu, A Klimas, X Chen… - PLoS computational …, 2013 - journals.plos.org
Channelrhodospin-2 (ChR2), a light-sensitive ion channel, and its variants have emerged as
new excitatory optogenetic tools not only in neuroscience, but also in other areas, including …

Three-dimensional nanofabrication via ultrafast laser patterning and kinetically regulated material assembly

F Han, S Gu, A Klimas, N Zhao, Y Zhao, SC Chen - Science, 2022 - science.org
A major challenge in nanotechnology is the fabrication of complex three-dimensional (3D)
structures with desired materials. We present a strategy for fabricating arbitrary 3D …

The evolution from weak to strong geomagnetic activity: An interpretation in terms of deterministic chaos

DN Baker, AJ Klimas, RL McPherron… - Geophysical Research …, 1990 - Wiley Online Library
Linear prediction filtering techniques have shown that the magnetospheric response to
energy transfer from the solar wind contains both driven and unloading components. Filter …

Self‐organized criticality in the substorm phenomenon and its relation to localized reconnection in the magnetospheric plasma sheet

AJ Klimas, JA Valdivia, D Vassiliadis… - Journal of …, 2000 - Wiley Online Library
Evidence is presented that suggests that there is a significant self‐organized criticality (SOC)
component in the dynamics of substorms in the magnetosphere. We assume that …