A decline in mitochondrial function plays a key role in the aging process and increases the
incidence of age-related disorders. A deeper understanding of the intricate nature of …

Skeletal muscle is a highly malleable tissue, capable of pronounced metabolic and
morphological adaptations in response to contractile activity(ie exercise). Each bout of contractile …

In today’s chaotic network, data and services are mobile and replicated widely for availability,
durability, and locality. Components within this infrastructure interact in rich and complex …

Human Protein Reference Database (HPRD) is an object database that integrates a wealth
of information relevant to the function of human proteins in health and disease. Data …

Background Approximately 50% of melanomas harbor activating (V600) mutations in the
serine–threonine protein kinase B-RAF (BRAF). The oral BRAF inhibitor vemurafenib (PLX4032…

We propose a remedy for the discrepancy between the way political scientists analyze data
with missing values and the recommendations of the statistics community. Methodologists …

INTRODUCTION Immunotherapy targeting the programmed cell death protein–1 (PD-1) axis
elicits durable antitumor responses in multiple cancer types. However, clinical responses …

MapReduce is emerging as an important programming model for large-scale data-parallel
applications such as web indexing, data mining, and scientific simulation. Hadoop is an open-…

Background Finerenone, a selective nonsteroidal mineralocorticoid receptor antagonist,
has favorable effects on cardiorenal outcomes in patients with predominantly stage 3 or 4 …

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G
are suggestive of a selective advantage but may also be due to a random founder effect. We …