User profiles for A. Hopkins

Andrew M. Hopkins

- Verified email at mq.edu.au - Cited by 33366

Andrew L. Hopkins

- Verified email at exscientia.co.uk - Cited by 26082

AG Hopkins

- Verified email at cam.ac.uk - Cited by 11960

How many drug targets are there?

JP Overington, B Al-Lazikani, AL Hopkins - Nature reviews Drug …, 2006 - nature.com
For the past decade, the number of molecular targets for approved drugs has been debated.
Here, we reconcile apparently contradictory previous reports into a comprehensive survey, …

The druggable genome

AL Hopkins, CR Groom - Nature reviews Drug discovery, 2002 - nature.com
An assessment of the number of molecular targets that represent an opportunity for therapeutic
intervention is crucial to the development of post-genomic research strategies within the …

Network pharmacology: the next paradigm in drug discovery

AL Hopkins - Nature chemical biology, 2008 - nature.com
The dominant paradigm in drug discovery is the concept of designing maximally selective
ligands to act on individual drug targets. However, many effective drugs act via modulation of …

On the evolution of star-forming galaxies

AM Hopkins - The Astrophysical Journal, 2004 - iopscience.iop.org
The evolution in the comoving space density of the global average galaxy star formation
rate (SFR) out to a redshift around unity is well established. Beyond z≈ 1 there is growing …

[BOOK][B] An economic history of West Africa

AG Hopkins - 2019 - taylorfrancis.com
This pioneering and celebrated work was the first, and remains the standard, account of the
economic history of the huge area conventionally known as West Africa. The book ranges …

[HTML][HTML] Tumor mutational burden and response rate to PD-1 inhibition

M Yarchoan, A Hopkins, EM Jaffee - New England Journal of …, 2017 - Mass Medical Soc
In a survey of the spectrum of mutational burdens in 27 types of cancers, there was a
correlation between an increased mutational burden and the response to checkpoint …

On the normalization of the cosmic star formation history

AM Hopkins, JF Beacom - The Astrophysical Journal, 2006 - iopscience.iop.org
Strong constraints on the cosmic star formation history (SFH) have recently been established
using ultraviolet and far-infrared measurements, refining the results of numerous …

Quantifying the chemical beauty of drugs

…, GV Paolini, J Besnard, S Muresan, AL Hopkins - Nature …, 2012 - nature.com
Drug-likeness is a key consideration when selecting compounds during the early stages of
drug discovery. However, evaluation of drug-likeness in absolute terms does not reflect …

Galaxy and Mass Assembly (GAMA): survey diagnostics and core data release

…, IK Baldry, SP Bamford, AM Hopkins… - Monthly Notices of …, 2011 - academic.oup.com
The Galaxy and Mass Assembly (GAMA) survey has been operating since 2008 February on
the 3.9-m Anglo-Australian Telescope using the AAOmega fibre-fed spectrograph facility to …

Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms

…, CA Parkos, JL Madara, AM Hopkins… - The Journal of …, 2003 - journals.aai.org
It is well known that inflammatory conditions of the intestinal mucosa result in compromised
barrier function. Inflammation is characterized by an influx into the mucosa of immune cells …