How many drug targets are there?
For the past decade, the number of molecular targets for approved drugs has been debated.
Here, we reconcile apparently contradictory previous reports into a comprehensive survey, …
Here, we reconcile apparently contradictory previous reports into a comprehensive survey, …
The druggable genome
AL Hopkins, CR Groom - Nature reviews Drug discovery, 2002 - nature.com
An assessment of the number of molecular targets that represent an opportunity for therapeutic
intervention is crucial to the development of post-genomic research strategies within the …
intervention is crucial to the development of post-genomic research strategies within the …
Network pharmacology: the next paradigm in drug discovery
AL Hopkins - Nature chemical biology, 2008 - nature.com
The dominant paradigm in drug discovery is the concept of designing maximally selective
ligands to act on individual drug targets. However, many effective drugs act via modulation of …
ligands to act on individual drug targets. However, many effective drugs act via modulation of …
On the evolution of star-forming galaxies
AM Hopkins - The Astrophysical Journal, 2004 - iopscience.iop.org
The evolution in the comoving space density of the global average galaxy star formation
rate (SFR) out to a redshift around unity is well established. Beyond z≈ 1 there is growing …
rate (SFR) out to a redshift around unity is well established. Beyond z≈ 1 there is growing …
[BOOK][B] An economic history of West Africa
AG Hopkins - 2019 - taylorfrancis.com
This pioneering and celebrated work was the first, and remains the standard, account of the
economic history of the huge area conventionally known as West Africa. The book ranges …
economic history of the huge area conventionally known as West Africa. The book ranges …
[HTML][HTML] Tumor mutational burden and response rate to PD-1 inhibition
M Yarchoan, A Hopkins, EM Jaffee - New England Journal of …, 2017 - Mass Medical Soc
In a survey of the spectrum of mutational burdens in 27 types of cancers, there was a
correlation between an increased mutational burden and the response to checkpoint …
correlation between an increased mutational burden and the response to checkpoint …
On the normalization of the cosmic star formation history
AM Hopkins, JF Beacom - The Astrophysical Journal, 2006 - iopscience.iop.org
Strong constraints on the cosmic star formation history (SFH) have recently been established
using ultraviolet and far-infrared measurements, refining the results of numerous …
using ultraviolet and far-infrared measurements, refining the results of numerous …
Quantifying the chemical beauty of drugs
Drug-likeness is a key consideration when selecting compounds during the early stages of
drug discovery. However, evaluation of drug-likeness in absolute terms does not reflect …
drug discovery. However, evaluation of drug-likeness in absolute terms does not reflect …
Galaxy and Mass Assembly (GAMA): survey diagnostics and core data release
The Galaxy and Mass Assembly (GAMA) survey has been operating since 2008 February on
the 3.9-m Anglo-Australian Telescope using the AAOmega fibre-fed spectrograph facility to …
the 3.9-m Anglo-Australian Telescope using the AAOmega fibre-fed spectrograph facility to …
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms
It is well known that inflammatory conditions of the intestinal mucosa result in compromised
barrier function. Inflammation is characterized by an influx into the mucosa of immune cells …
barrier function. Inflammation is characterized by an influx into the mucosa of immune cells …