Both genome-wide genetic and epigenetic alterations are fundamentally important for the
development of cancers, but the interdependence of these aberrations is poorly understood. …

Annotation of prostate cancer genomes provides a foundation for discoveries that can
impact disease understanding and treatment. Concordant assessment of DNA copy number, …

Background Acute myeloid leukemia (AML) is a heterogeneous disease with respect to
presentation and clinical outcome. The prognostic value of recently identified somatic mutations …

Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and
by increased risk of myeloid malignancies. Exome sequencing of three elderly females with …

The bone marrow microenvironment has a key role in regulating haematopoiesis, but its
molecular complexity and response to stress are incompletely understood. Here we map the …

Background Uveal melanoma is the most common intraocular cancer. There are no effective
therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit …

Patients with poorly differentiated thyroid cancers (PDTC), anaplastic thyroid cancers (ATC),
and radioactive iodine-refractory (RAIR) differentiated thyroid cancers have a high mortality, …

Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer
treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein 1 . …

Glioblastoma is one of the most challenging forms of cancer to treat. Here we describe a
computational platform that integrates the analysis of copy number variations and somatic …

Adenoid cystic carcinomas (ACCs) are among the most enigmatic of human malignancies.
These aggressive salivary gland cancers frequently recur and metastasize despite definitive …