Despite the global impact of macrophage activation in vascular disease, the underlying
mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage cell …

Many complex systems can be described as multiplex networks in which the same nodes
can interact with one another in different layers, thus forming a set of interacting and co-…

Background: Chronic kidney disease (CKD) increases cardiovascular risk. Underlying
mechanisms, however, remain obscure. The uremic toxin indoxyl sulfate is an independent …

Untangling the complex interplay between phenotype and genotype is crucial to the effective
characterization and subtyping of diseases. Here we build and analyze the multiplex …

Extracellular vesicles (EVs) including plasma membrane–derived microvesicles and
endosomal-derived exosomes aggregate by unknown mechanisms, forming microcalcifications that …

Background: No pharmacological therapy exists for calcific aortic valve disease (CAVD),
which confers a dismal prognosis without invasive valve replacement. The search for …

Background: Activated macrophages contribute to the pathogenesis of vascular disease.
Vein graft failure is a major clinical problem with limited therapeutic options. PCSK9 (proprotein …

Aims Calcific aortic valve disease (CAVD) is the most common valve disease, which consists
of a chronic interplay of inflammation, fibrosis, and calcification. In this study, sortilin (SORT1…

Robustness is a prominent feature of most biological systems. Most previous related studies
have been focused on homogeneous molecular networks. Here we propose a …

Distributed generation takes center stage in today’s rapidly changing energy landscape.
Particularly, locally matching demand and generation in the form of microgrids is becoming a …