Antibody fragments of predetermined binding specificity have recently been constructed from
repertoires of antibody V genes, bypassing hybridoma technology and even immunization. …

Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus (EBOV).
EVD outbreaks typically start from a single case of probable zoonotic transmission, …

Biochemical and genetic assays can be both miniaturized and parallelized by compartmentalization
in living cells. In vitro compartmentalization (IVC) offers an alternative strategy …

Background The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE)
initiative of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD…

Inflammatory bowel diseases (IBDs), including Crohn's disease (CD), are genetically linked
to host pathways that implicate an underlying role for aberrant immune responses to …

We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS)
comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the …

Several risk factors for Crohn's disease have been identified in recent genome-wide association
studies. To advance gene discovery further, we combined data from three studies on …

Transmission genetic analysis: Patterns of inheritance-The chromosomal basic of
inheritance-Eukaryote chromosome mapping by recombination-The genetics of bacteria and their …

We present a genome-wide association study of ileal Crohn disease and two independent
replication studies that identify several new regions of association to Crohn disease. …

Objective We aimed to provide an evidence-supported update of the ECCO-ESPGHAN
guideline on the medical management of paediatric Crohn’s disease [CD]. Methods We formed …