Historical introgression among the American live oaks and the comparative nature of tests for introgression
Introgressive hybridization challenges the concepts we use to define species and infer
phylogenetic relationships. Methods for inferring historical introgression from the genomes of …
phylogenetic relationships. Methods for inferring historical introgression from the genomes of …
[HTML][HTML] Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?
P Rada, Á González-Rodríguez, C García-Monzón… - Cell death & …, 2020 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver
disease worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …
disease worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …
[HTML][HTML] Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD
A Gonzalez-Rodriguez, R Mayoral, N Agra… - Cell death & …, 2014 - nature.com
The pathogenic mechanisms underlying the progression of non-alcoholic fatty liver disease (NAFLD)
are not fully understood. In this study, we aimed to assess the relationship between …
are not fully understood. In this study, we aimed to assess the relationship between …
Genomic landscape of the global oak phylogeny
…, A González‐Rodríguez… - New …, 2020 - Wiley Online Library
The tree of life is highly reticulate, with the history of population divergence emerging from
populations of gene phylogenies that reflect histories of introgression, lineage sorting and …
populations of gene phylogenies that reflect histories of introgression, lineage sorting and …
[HTML][HTML] LAG-3 blockade with relatlimab (BMS-986016) restores anti-leukemic responses in chronic lymphocytic leukemia
…, S Lorenzo-Herrero, AP González-Rodríguez… - Cancers, 2021 - mdpi.com
Simple Summary Patients with chronic lymphocytic leukemia (CLL), the most frequent B cell
malignancy in western countries, develop a progressive immunosuppression, leading to …
malignancy in western countries, develop a progressive immunosuppression, leading to …
Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice
A González-Rodríguez, JAM Gutierrez… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Mice with complete deletion of insulin receptor substrate 2 (IRS2) develop
hyperglycemia, impaired hepatic insulin signaling, and elevated gluconeogenesis, whereas mice …
hyperglycemia, impaired hepatic insulin signaling, and elevated gluconeogenesis, whereas mice …
Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection
V Pardo, Á González-Rodríguez, J Muntané… - Food and Chemical …, 2015 - Elsevier
The excess of saturated free fatty acids, such as palmitic acid, that induces lipotoxicity in
hepatocytes, has been implicated in the development of non-alcoholic fatty liver disease also …
hepatocytes, has been implicated in the development of non-alcoholic fatty liver disease also …
[HTML][HTML] Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis
…, ME Rodríguez, Á González-Rodríguez… - The Journal of …, 2012 - Am Soc Clin Investig
Bacterial LPS (endotoxin) has been implicated in the pathogenesis of acute liver disease
through its induction of the proinflammatory cytokine TNF-α. TNF-α is a key determinant of the …
through its induction of the proinflammatory cytokine TNF-α. TNF-α is a key determinant of the …
SIRT1 controls acetaminophen hepatotoxicity by modulating inflammation and oxidative stress
…, L Ruiz, Á González-Rodríguez… - Antioxidants & redox …, 2018 - liebertpub.com
Aims: Sirtuin 1 (SIRT1) is a key player in liver physiology and a therapeutic target against
hepatic inflammation. We evaluated the role of SIRT1 in the proinflammatory context and …
hepatic inflammation. We evaluated the role of SIRT1 in the proinflammatory context and …
Essential role of protein tyrosine phosphatase 1B in obesity‐induced inflammation and peripheral insulin resistance during aging
Á González‐Rodríguez, JA Más‐Gutierrez… - Aging cell, 2012 - Wiley Online Library
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling and a
therapeutic target for type 2 diabetes (T2DM). In this study, we have evaluated the role of …
therapeutic target for type 2 diabetes (T2DM). In this study, we have evaluated the role of …