INTRODUCTION We used genomic epidemiology to investigate the introduction and spread
of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Boston area …

The 2013–2016 West African epidemic caused by the Ebola virus was of unprecedented
magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of …

Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects
have attracted a great deal of attention 1 , 2 , much remains unknown about ZIKV disease …

Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities
1 , 2 . In July 2016, mosquito-borne ZIKV transmission was reported in the continental …

The 2013–2015 Ebola virus disease (EVD) epidemic is caused by the Makona variant of
Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights into virus …

During 2018, an unusual increase in Lassa fever cases occurred in Nigeria, raising concern
among national and international public health agencies. We analyzed 220 Lassa virus …

Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent
genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs, …

Metagenomic sequencing has the potential to transform microbial detection and
characterization, but new tools are needed to improve its sensitivity. Here we present CATCH, a …

Effective interpretation of genome function and genetic variation requires a shift from epigenetic
mapping of cis-regulatory elements (CREs) to characterization of endogenous function. …

SARS-CoV-2 has caused a severe, ongoing outbreak of COVID-19 in Massachusetts with
111,070 confirmed cases and 8,433 deaths as of August 1, 2020. To investigate the …