Large-scale genetic studies are highly dependent on efficient and scalable multiplex SNP
assays. In this study, we report the development of Molecular Inversion Probe technology with …

Recent genome-wide association studies (GWAS) have identified 35 loci that significantly
associate with coronary artery disease (CAD) susceptibility. The majority of the genes …

Heparan sulfate proteoglycans (HSPGs) are an important constituent of the macrophage
glycocalyx and extracellular microenvironment. To examine their role in atherogenesis, we …

Objective— The objective of this study was to determine the basis of resistance to
atherosclerosis of inbred mouse strain BALB/cJ. Approach and Results— BALB/cJ mice carry a …

Objective— Endothelial cells are central to the initiation of atherosclerosis, yet there has been
limited success in studying their gene expression in the mouse aorta. To address this, we …

Background— We previously mapped a quantitative trait locus on chromosome 15 in mice
contributing to high-density lipoprotein cholesterol and triglyceride levels and now report the …

Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions
underlying this disease remains incomplete. Here, we harvest 1352 healthy and failing …

Objective— The purpose of this study was to fine map previously identified quantitative trait
loci affecting atherosclerosis in mice using association analysis. Methods and Results— We …

Single nucleotide polymorphisms (SNPs) that lead to non-synonymous changes in proteins
may have functional effects and be subject to selection. Hence they are of particular interest …

Coniferous trees are often dominant species in both boreal and temperate forests, wherein
they play critical roles in ecosystem function. In natural environments, ecosystem stability …