The dogma that adaptive immunity is the only arm of the immune response with memory
capacity has been recently challenged by several studies demonstrating evidence for memory-…

Infectious diseases are among the strongest selective pressures driving human evolution 1 ,
2 . This includes the single greatest mortality event in recorded history, the first outbreak of …

Individuals from different populations vary considerably in their susceptibility to immune-related
diseases. To understand how genetic variation and natural selection contribute to these …

Objective: Oestrogen withdrawal has been hypothesized as playing a causal role in puerperal
psychoses. However, oestrogen withdrawal exists in conditions others than puerperium. …

DNA methylation is an epigenetic mark thought to be robust to environmental perturbations
on a short time scale. Here, we challenge that view by demonstrating that the infection of …

Coeliac disease is a complex, polygenic inflammatory enteropathy caused by exposure to
dietary gluten that occurs in a subset of genetically susceptible individuals who express either …

Epidemiological and genome-wide association studies of severe psychiatric disorders such
as schizophrenia (SZ) and bipolar disorder (BD), suggest complex interactions between …

Background The 2’-5’ oligoadenylate synthetase (OAS) locus encodes for three OAS
enzymes (OAS1-3) involved in innate immune response. This region harbors high amounts of …

DNA methylation is considered to be a relatively stable epigenetic mark. However, a growing
body of evidence indicates that DNA methylation levels can change rapidly; for example, in …

Primary sclerosing cholangitis (PSC) is an immune-mediated disease of the bile ducts that
co-occurs with inflammatory bowel disease (IBD) in almost 90% of cases. Colorectal cancer is …