This paper presents the results of a functional-integral approach to the dynamics of a two-state
system coupled to a dissipative environment. It is primarily an extended account of results …

Classically, G protein-coupled receptor (GPCR) stimulation promotes G protein signaling at
the plasma membrane, followed by rapid β-arrestin-mediated desensitization and receptor …

As a result of evolutionary selection, the subunits of naturally occurring protein assemblies
often fit together with substantial shape complementarity to generate architectures optimal for …

G-protein-coupled receptors (GPCRs) are critically regulated by β-arrestins, which not only
desensitize G-protein signalling but also initiate a G-protein-independent wave of signalling 1 …

Characterizing cell surface receptors mediating viral infection is critical for understanding
viral tropism and developing antiviral therapies. Nevertheless, due to challenges associated …

The polyketide synthase (PKS) mega-enzyme assembly line uses a modular architecture to
synthesize diverse and bioactive natural products that often constitute the core structures or …

Despite abundant knowledge of the regulation and biochemistry of glycolytic enzymes, we
have limited understanding on how they are spatially organized in the cell. Emerging …

The isolation of CCoV-HuPn-2018 from a child respiratory swab indicates that more
coronaviruses are spilling over to humans than previously appreciated. We determined the …

We study the fluctuation Ettingshausen effect in a type-II superconductor using the time-dependent
Ginzburg-Landau equation. The free-fluctuation theory predicts a divergence in the …

Stream water often diverges from the main channel into sediments below the stream surface,
gravel bars next to the stream, or organic debris dams in the middle of the stream. These …