User profiles for A. Dhroso
 | Andi DhrosoPhD student, Worcester Polytechnic Institue Verified email at wpi.edu Cited by 315 |
The variation game: Cracking complex genetic disorders with NGS and omics data
Tremendous advances in Next Generation Sequencing (NGS) and high-throughput omics
methods have brought us one step closer towards mechanistic understanding of the complex …
methods have brought us one step closer towards mechanistic understanding of the complex …
Systematic mutagenesis of serine hydroxymethyltransferase reveals an essential role in nematode resistance
Rhg4 is a major genetic locus that contributes to soybean cyst nematode (SCN) resistance
in the Peking-type resistance of soybean (Glycine max), which also requires the rhg1 gene. …
in the Peking-type resistance of soybean (Glycine max), which also requires the rhg1 gene. …
Biological classification with RNA-seq data: Can alternatively spliced transcript expression enhance machine learning classifiers?
RNA sequencing (RNA-seq) is becoming a prevalent approach to quantify gene expression
and is expected to gain better insights into a number of biological and biomedical questions …
and is expected to gain better insights into a number of biological and biomedical questions …
[HTML][HTML] Novel global effector mining from the transcriptome of early life stages of the soybean cyst nematode Heterodera glycines
Soybean cyst nematode (SCN) Heterodera glycines is an obligate parasite that relies on the
secretion of effector proteins to manipulate host cellular processes that favor the formation …
secretion of effector proteins to manipulate host cellular processes that favor the formation …
Phytonematode peptide effectors exploit a host post‐translational trafficking mechanism to the ER using a novel translocation signal
Cyst nematodes induce a multicellular feeding site within roots called a syncytium. It
remains unknown how root cells are primed for incorporation into the developing syncytium. …
remains unknown how root cells are primed for incorporation into the developing syncytium. …
Open community challenge reveals molecular network modules with key roles in diseases
Identification of modules in molecular networks is at the core of many current analysis
methods in biomedical research. However, how well different approaches identify disease-…
methods in biomedical research. However, how well different approaches identify disease-…
[HTML][HTML] Tools for annotation and comparison of structural variation
FJ Sedlazeck, A Dhroso, DL Bodian, J Paschall… - …, 2017 - ncbi.nlm.nih.gov
The impact of structural variants (SVs) on a variety of organisms and diseases like cancer
has become increasingly evident. Methods for SV detection when studying genomic …
has become increasingly evident. Methods for SV detection when studying genomic …
[HTML][HTML] Genome-wide prediction of bacterial effector candidates across six secretion system types using a feature-based statistical framework
Gram-negative bacteria are responsible for hundreds of millions infections worldwide,
including the emerging hospital-acquired infections and neglected tropical diseases in the third-…
including the emerging hospital-acquired infections and neglected tropical diseases in the third-…
Short-stalked Prosthecomicrobium hirschii cells have a Caulobacter-like cell cycle
The dimorphic alphaproteobacterium Prosthecomicrobium hirschii has both short-stalked
and long-stalked morphotypes. Notably, these morphologies do not arise from transitions in a …
and long-stalked morphotypes. Notably, these morphologies do not arise from transitions in a …
DOMMINO 2.0: integrating structurally resolved protein-, RNA-, and DNA-mediated macromolecular interactions
Macromolecular interactions are formed between proteins, DNA and RNA molecules. Being
a principle building block in macromolecular assemblies and pathways, the interactions …
a principle building block in macromolecular assemblies and pathways, the interactions …