The genome of measles virus is encapsidated by multiple copies of the nucleoprotein (N),
forming helical nucleocapsids of molecular mass approaching 150 Megadalton. The …

Measles is a highly contagious human disease. We used cryo–electron microscopy and
single particle–based helical image analysis to determine the structure of the helical …

The target of rapamycin (TOR) is a eukaryotic serine/threonine protein kinase that functions
in two distinct complexes, TORC1 and TORC2, to regulate growth and metabolism 1 , 2 . …

Helical reconstruction from electron cryomicrographs has become a routine technique for
macromolecular structure determination of helical assemblies since the first days of Fourier-…

The class III receptor tyrosine kinase (RTKIII) Fms-like tyrosine kinase receptor 3 (Flt3) and
its cytokine ligand (FL) play central roles in hematopoiesis and the immune system, by …

Centrioles and basal bodies are essential for the formation of cilia, flagella, and centrosomes.
They exhibit a characteristic ninefold symmetry imparted by a cartwheel thought to contain …

The endosomal sorting complex required for transport (ESCRT) is a highly conserved protein
machinery that drives a divers set of physiological and pathological membrane remodeling …

The highly conserved eukaryotic Elongator complex performs specific chemical modifications
on wobble base uridines of tRNA s, which are essential for proteome stability and …

Clathrin-mediated endocytosis, the main trafficking route from the plasma membrane to the
cytoplasm, is critical to many fundamental cellular processes. Clathrin, coupled to the …

Actins are highly conserved proteins and key players in central processes in all eukaryotic
cells. The two actins of the malaria parasite are among the most divergent eukaryotic actins …