Objective— Transfusion of aged blood has been associated with increased morbidity and
mortality in critically ill patients. During storage, erythrocytes release increasing numbers of …

Conditioned place preference (CPP) is a widely used model of addiction-related behavior
whose underlying mechanisms are not understood. In this study, we used dual site silicon …

Maturation of B cells within germinal centers (GCs) generates diversified B cell pools and
high-affinity B cell antigen receptors (BCRs) for pathogen clearance. Increased receptor affinity …

Objectives Gout is a highly inflammatory but self-limiting joint disease induced by the
precipitation of monosodium urate (MSU) crystals. While it is well established that inflammasome …

… Cumpelik, Arun; Heeger, Peter S. … In 2021, Cumpelik et al. showed that coordinate,
physiological repression of complement regulators on germinal center B cells enables local …

T cell–independent (TI) B cell responses to nonprotein Ags involve multiple cues from the
innate immune system. Neutrophils express complement receptors and activated neutrophils …

Herein, we report that Shroom3 knockdown, via Fyn inhibition, induced albuminuria with
foot process effacement (FPE) without focal segmental glomerulosclerosis (FSGS) or …

Background Although high-affinity IgG auto-and alloantibodies are important drivers of kidney
inflammation that can result in ESKD, therapeutic approaches that effectively reduce such …

Background We previously showed that the presence of a CKD-associated locus in
SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin–binding …

T cell depletion with antithymocyte globulins (ATG) can be complicated by thrombopenia
and hypercoagulability. The underlying mechanism is still unclear. We found that binding of …