User profiles for A. Csikasz-Nagy

Attila Csikász-Nagy

Pázmány Péter Catholic University, Hungary
Verified email at itk.ppke.hu
Cited by 4943

The dynamics of cell cycle regulation

JJ Tyson, A CsikaszNagy, B Novak - Bioessays, 2002 - Wiley Online Library
Major events of the cell cycle—DNA synthesis, mitosis and cell division—are regulated by a
complex network of protein interactions that control the activities of cyclin‐dependent kinases…

Integrative analysis of cell cycle control in budding yeast

KC Chen, L Calzone, A Csikasz-Nagy… - Molecular biology of …, 2004 - Am Soc Cell Biol
The adaptive responses of a living cell to internal and external signals are controlled by
networks of proteins whose interactions are so complex that the functional integration of the …

Computational systems biology of the cell cycle

A Csikasz-Nagy - Briefings in bioinformatics, 2009 - academic.oup.com
One of the early success stories of computational systems biology was the work done on cell-cycle
regulation. The earliest mathematical descriptions of cell-cycle control evolved into …

[HTML][HTML] The cell cycle switch computes approximate majority

L Cardelli, A Csikász-Nagy - Scientific reports, 2012 - nature.com
Both computational and biological systems have to make decisions about switching from
one state to another. The ‘Approximate Majority’ computational algorithm provides the …

[HTML][HTML] Analysis of a generic model of eukaryotic cell-cycle regulation

A Csikász-Nagy, D Battogtokh, KC Chen, B Novák… - Biophysical journal, 2006 - cell.com
We propose a protein interaction network for the regulation of DNA synthesis and mitosis
that emphasizes the universality of the regulatory system among eukaryotic cells. The …

Kinetic analysis of a molecular model of the budding yeast cell cycle

KC Chen, A Csikasz-Nagy, B Gyorffy, J Val… - Molecular biology of …, 2000 - Am Soc Cell Biol
The molecular machinery of cell cycle control is known in more detail for budding yeast,
Saccharomyces cerevisiae, than for any other eukaryotic organism. In recent years, many …

[HTML][HTML] The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation

…, E Garí, C Gallego, A Csikász-Nagy… - Nature …, 2012 - nature.com
Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain
a critical size set by external conditions. However, arguing against deterministic models of …

Irreversible cell-cycle transitions are due to systems-level feedback

B Novak, JJ Tyson, B Gyorffy, A Csikasz-Nagy - Nature cell biology, 2007 - nature.com
The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible
degradation of certain regulatory proteins. We argue that irreversible transitions in the cell …

Circadian rhythms synchronize mitosis in Neurospora crassa

…, WJ Belden, A Csikász-Nagy - Proceedings of the …, 2014 - National Acad Sciences
The cell cycle and the circadian clock communicate with each other, resulting in circadian-gated
cell division cycles. Alterations in this network may lead to diseases such as cancer. …

[HTML][HTML] An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology

…, Y Shen, W Fontana, H Lu, A Csikasz-Nagy… - PLoS …, 2014 - journals.plos.org
Insulin-like peptides (ILPs) play highly conserved roles in development and physiology.
Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty …