Sensory primary afferent fibers, conveying touch, pain, itch, and proprioception, synapse onto
spinal cord dorsal horn neurons. Primary afferent central terminals express a wide variety …

Molecular mechanisms underlying apoptosis in retinitis pigmentosa, as in other neurodegenerative
diseases, are still elusive, and this fact hampers the development of a cure for this …

The bacterial CRISPR/Cas system has proven to be an efficient tool for genetic manipulation
in various organisms. Here we show the application of CRISPR-Cas9 technology to edit the …

Sulla base dell'analisi contenuta nell'ottava relazione sulla coesione, la presente comunicazione
illustra i principali cambiamenti a livello di disparità territoriali nel corso del decennio …

Purpose.: The process of photoreceptor cell death in retinitis pigmentosa is still not well
characterized, and identification of common mechanisms will be instrumental for development of …

Calcium ions play a critical role in neuronal cell death. Pigment epithelium-derived factor (PEDF)
is a promising neuroprotective protein for photoreceptor cells but the mechanisms …

Cone photoreceptor cell death as it occurs in certain hereditary retinal diseases is devastating,
with the affected patients suffering from a loss of accurate and colour vision. Regrettably, …

PRPF3 is an element of the splicing machinery ubiquitously expressed, yet mutations in this
gene are associated with a tissue-specific phenotype: autosomal dominant retinitis …

It has been known that algogens and cooling could inhibit itch sensation; however, the
underlying molecular and neural mechanisms remain poorly understood. Here, we show that the …

The autosomal dominant form of retinitis pigmentosa (adRP) is a blindness-causing
conformational disease largely linked to mutations of rhodopsin. Molecular simulations coupled to …