The primary cellular source of factor VIII (FVIII) biosynthesis is controversial, with contradictory
evidence supporting an endothelial or hepatocyte origin. LMAN1 is a cargo receptor in the …

Thrombo-inflammation describes the complex interplay between blood coagulation and
inflammation that plays a critical role in cardiovascular diseases. The third Maastricht …

Endothelial cells (ECs) are highly specialized across vascular beds. However, given their
interspersed anatomic distribution, comprehensive characterization of the molecular basis for …

Macrophages resident in different organs express distinct genes, but understanding how this
diversity fits into tissue-specific features is limited. Here, we show that selective expression …

Background: Oral estrogen use is associated with changes in plasma levels of many coagulation
proteins. Objective: To gain more insight into the underlying mechanism of estrogen‐…

In the last decades, it has become evident that endothelial cells (ECs) in the microvasculature
play an important role in the pathophysiology of sepsis-associated multiple organ …

Background Urinary CD80 has emerged as potential biomarker in idiopathic nephrotic
syndrome (INS). However, its cellular source remains controversial. The aim of the study was to …

Although it is caused by a single-nucleotide mutation in the β-globin gene, sickle cell
anemia (SCA) is a systemic disease with complex, incompletely elucidated pathologies. The …

BACKGROUND: During infectious diseases, proinflammatory cytokines transiently destabilize
interactions between adjacent vascular endothelial cells (ECs) to facilitate the passage of …

During the last 15 years, transgenic mice have been generated that carry defective and/or
mutant alleles of the natural anticoagulant pathways and display a spontaneous thrombotic …