K + channel principal subunits are by far the largest and most diverse of the ion channels. This
diversity originates partly from the large number of genes coding for K + channel principal …

Immunotherapy has been a remarkable clinical advancement in the treatment of cancer. T
cells are pivotal to the efficacy of current cancer immunotherapies, including immune-…

With the rapidly growing popularity and sophistication of inhalation therapy, there is an
increasing demand for tailor-made inhalable drug particles capable of affording the most efficient …

Despite accumulating evidence suggesting local self-maintenance of tissue macrophages
in the steady state, the dogma remains that tissue macrophages derive from monocytes. …

We assessed gene expression in tissue macrophages from various mouse organs. The
diversity in gene expression among different populations of macrophages was considerable. …

Evidence-based guidelines for managing patients with intra-abdominal infection were prepared
by an Expert Panel of the Surgical Infection Society and the Infectious Diseases Society …

Cancer-secreted microRNAs (miRNAs) are emerging mediators of cancer-host crosstalk.
Here we show that miR-105, which is characteristically expressed and secreted by metastatic …

Many long non-coding RNAs (lncRNAs) affect gene expression 1 , but the mechanisms by
which they act are still largely unknown 2 . One of the best-studied lncRNAs is Xist, which is …

To guide the design of immunotherapy strategies for patients with early stage lung tumors,
we developed a multiscale immune profiling strategy to map the immune landscape of early …

Background Three clusters of coronavirus disease 2019 (COVID-19) linked to a tour group
from China, a company conference, and a church were identified in Singapore in February, …