Microtubules are essential for polarized transport in neurons, but how their organization
guides motor proteins to axons or dendrites is unclear. Because different motors recognize …

In the central nervous system, most excitatory post-synapses are small subcellular structures
called dendritic spines. Their structure and morphological remodeling are tightly coupled to …

Axon formation, the initial step in establishing neuronal polarity, critically depends on local
microtubule reorganization and is characterized by the formation of parallel microtubule …

Actin dynamics drive morphological remodeling of neuronal dendritic spines and changes
in synaptic transmission. Yet, the spatiotemporal coordination of actin regulators in spines is …

The development and homeostasis of neurons relies heavily on the selective targeting of
vesicles into axon and dendrites. Microtubule-based motor proteins play an important role in …

The spatiotemporal coordination of actin regulators in the lamellipodium determines the
dynamics and architecture of branched F-actin networks during cell migration. The WAVE …

Multicolor single-molecule localization microscopy (λSMLM) is a powerful technique to
reveal the relative nanoscale organization and potential colocalization between different …

Neuron morphology and function are highly dependent on proper organization of the
cytoskeleton. In neurons, the centrosome is inactivated early in development, and acentrosomal …

The morphology of neuronal dendritic spines is a critical indicator of synaptic function. It is
regulated by several factors, including the intracellular actin/myosin cytoskeleton and …

The formation and maintenance of highly polarized neurons critically depends on the proper
organization of the microtubule (MT) cytoskeleton. In axons, MTs are uniformly oriented with …