Background. Strain typing is a tool for determining the diversity and epidemiology of infections.
Methods. Treponema pallidum DNA was isolated from 158 patients with syphilis from the …

Fundamental understanding of rabbit immunology and the use of the rabbit as a disease
model have long been hindered by the lack of immunological assays specific to this species. In …

The species Treponema pallidum includes three subspecies (pallidum, pertenue, and
endemicum) that cause syphilis, yaws, and bejel, respectively. A closely related species, …

Treponema pallidum subsp. pallidum, the causative agent of venereal syphilis, was detected
in a 200-year-old skeletal specimen from Easter Island. An initial diagnosis of treponemal …

We have identified a family of genes that code for targets for opsonic antibody and protective
immunity in T. pallidum subspecies pallidum using two different approaches, subtraction …

The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century
established this devastating infectious disease as one of the most feared in human history 1. …

Pathogens that cause chronic infections often employ antigenic variation to evade the
immune response and persist in the host. In Treponema pallidum (T. pallidum), the causative …

The tprK gene sequence of Treponema pallidum subspecies pallidum (T. pallidum) is
heterogeneous within and among isolates. Heterogeneity in the tprK open reading frame is …

We have previously shown that the TprK antigen of T. pallidum, Nichols strain, is predominantly
expressed in treponemes obtained 10 days after infection and that the hydrophilic …

To determine whether the 23S rRNA mutation that confers macrolide resistance is present
in >1 Treponema pallidum strain, 58 isolates collected between 2001 and 2005 were …