The retina is an easily accessible part of the CNS with a well-defined cytological architecture.
It allows for detailed study of the regulation of neurogenesis, determinants of cell fate …

Most research on mechanisms of aging is being conducted in a very limited number of classical
model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus domestica), …

Aging research in vertebrates is hampered by the lack of short‐lived models. Annual fishes
of the genus Nothobranchius live in East African seasonal ponds. Their life expectancy in the …

Resveratrol, a natural phytoalexin found in grapes and red wine [1], increases longevity in
the short-lived invertebrates Caenorhabditis elegans and Drosophila [2–5] and exerts a …

Temperature variations are known to modulate aging and life‐history traits in poikilotherms
as different as worms, flies and fish. In invertebrates, temperature affects lifespan by …

Evolutionary theories of senescence postulate that lifespan is determined by the age-dependent
decrease in the effects of natural selection. Factors that influence survival and …

Background A laboratory inbred strain of the annual fish Nothobranchius furzeri shows
exceptionally short life expectancy and accelerated expression of age markers. In this study, we …

While brain-derived neurotrophic factor (BDNF) delays the death of axotomized retinal
ganglion cells in rodents, it is unclear if it affects any aspect of the normal development of these …

A progressive loss of protein homeostasis is characteristic of aging and a driver of
neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics …

The brains of teleost fish show extensive adult neurogenesis and neuronal regeneration.
The patterns of gene regulation during fish brain aging are unknown. The short‐lived teleost …