Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types

S Chun, A Casparino, NA Patsopoulos… - Nature …, 2017 - nature.com
Most autoimmune-disease-risk effects identified by genome-wide association studies (GWAS)
localize to open chromatin with gene-regulatory activity. GWAS loci are also enriched in …

Methodologies for the application of calcium compounds in agropastoral systems: Effects on crop yields

…, JL Hipólito, FS Tokuda, AC Gasparino… - Agronomy …, 2021 - Wiley Online Library
Soil acidity (pH <4.4) restricts exploration by the root system and impairs crop yield. To
contribute to the development of alternative methodologies for correcting acidity in the surface …

[HTML][HTML] Lean healthcare tools for processes evaluation: an integrative review

…, EBB Zeferino, V Minatogawa, RC Gasparino - International journal of …, 2021 - mdpi.com
Several health services have used lean healthcare to seek continuous improvement of their
processes. Therefore, it is important to investigate the evidence available in the literature …

The influence of nursing leadership styles on the outcomes of patients, professionals and institutions: An integrative review

…, J Altafini, FCP Dias, RC Gasparino - Journal of Nursing …, 2022 - Wiley Online Library
Aim This review was conducted to map leadership styles that positively impact patients,
professionals and institutions. Background Leadership is a topic widely studied because it is a …

[HTML][HTML] Effect of a monoclonal antibody to PCSK9 on LDL cholesterol

…, R Wu, Y Du, T Kranz, E Gasparino… - … England Journal of …, 2012 - Mass Medical Soc
Background Proprotein convertase subtilisin/kexin 9 (PCSK9), one of the serine proteases,
binds to low-density lipoprotein (LDL) receptors, leading to their accelerated degradation and …

Measuring the impact of tourism upon urban economies: a review of literature

U Gasparino, E Bellini, B Del Corpo, W Malizia - 2008 - papers.ssrn.com
Tourism is increasingly seen as a potential lever towards high economic growth, measured
both in terms of income and employment. In recent years, interest in tourism has spread …

Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo …

…, E Nanna, EH O'Keefe, E Gasparino… - The Lancet Infectious …, 2022 - thelancet.com
Background There is an unmet need for COVID-19 prevention in patient populations who
have not mounted or are not expected to mount an adequate immune response to complete …

Prophylactic dressings in the prevention of pressure ulcer related to the use of personal protective equipment by health professionals facing the COVID‐19 pandemic …

RC Gasparino, MHM Lima… - Wound Repair and …, 2021 - Wiley Online Library
Device‐related pressure injury (DRPI) is a serious problem that is affecting professionals
working on the front lines against COVID‐19 due to the prolonged use of personal protective …

[HTML][HTML] A randomized study investigating the safety, tolerability, and pharmacokinetics of evinacumab, an ANGPTL3 inhibitor, in healthy Japanese and Caucasian …

M Harada-Shiba, S Ali, DA Gipe, E Gasparino, V Son… - Atherosclerosis, 2020 - Elsevier
Background and aims Evinacumab, an angiopoietin-like protein 3 monoclonal antibody,
reduced low-density lipoprotein cholesterol (LDL-C) significantly in a Phase 2 study of patients …

[HTML][HTML] Shared effect modeling reveals that a fraction of autoimmune disease associations are consistent with eQTLs in three immune cell types

S Chun, A Casparino, NA Patsopoulos… - bioRxiv, 2016 - biorxiv.org
The majority of autoimmune disease risk effects identified by genome-wide association
studies (GWAS) localize to open chromatin with gene regulatory activity. GWAS loci are also …