Steatosis--accumulation of triacylglycerol in hepatocytes--is a common finding in liver biopsy
specimens. The commonest form is macrovesicular change, which occurs in response to a …

Liver damage leads to an inflammatory response and to the activation and proliferation of
mesenchymal cell populations within the liver which remodel the extracellular matrix as part of …

The tumour microenvironment, also termed the tumour stroma or tumour mesenchyme,
includes fibroblasts, immune cells, blood vessels and the extracellular matrix and substantially …

Since the completion of the genome sequence of Saccharomyces cerevisiae in 1996 (refs 1
), there has been a large increase in complete genome sequences, accompanied by great …

… Just over ten years ago, Trivers joined forces with geneticist Austin Burt for a detailed
study of selfish genetic elements, and Genes in Conflict is the result of their fruitful …

Linkage disequilibrium is an ubiquitous biological phenomenon. However a common metric
for disequilibrium – the index of association or I A – is dependent on sample size. In this …

Background and Aims There remains uncertainty about the natural history of non-alcoholic
fatty liver disease (NAFLD). The spectrum of NAFLD includes non-alcoholic fatty liver (NAFL; …

The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular
senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of …

The detection of fibrosis within nonalcoholic fatty liver disease (NAFLD) is important for
ascertaining prognosis and the stratification of patients for emerging therapeutic intervention. We …

Height is a highly heritable, classic polygenic trait with approximately 700 common associated
variants identified through genome-wide association studies so far. Here, we report 83 …