During the past two decades, the field of mammalian myocardial regeneration has grown
dramatically, and with this expanded interest comes increasing claims of experimental …

Tissue regenerative potential displays striking divergence across phylogeny and ontogeny,
but the underlying mechanisms remain enigmatic. Loss of mammalian cardiac regenerative …

Long noncoding RNAs (lncRNAs) are prevalent genes with frequently precise regulation but
mostly unknown functions. Here we demonstrate that lncRNAs guide the organismal DNA …

Post-translational regulation of protein abundance in cells is a powerful tool for studying
protein function. Here, we describe a novel genetically encoded protein domain that is …

… Payumo's lab at San Jose State University for thoughtful conversations and input. All figures
… Payumo, and NIH awards (R01HL138456 and R01HL157280), American Heart Association …

Newborn mice possess a robust but transient capacity for heart regeneration that is lost when
cardiomyocytes permanently exit the cell cycle and binucleate during the first week after …

Hedgehog (Hh) pathway activation and Gli-dependent transcription play critical roles in
embryonic patterning, tissue homeostasis, and tumorigenesis. By conducting a genome-scale …

Using genome-wide transcriptional profiling and whole-mount expression analyses of zebrafish
larvae, we have identified hyaluronan synthase 3 (has3) as an upregulated gene during …

While adult zebrafish and newborn mice possess a robust capacity to regenerate their
hearts, this ability is generally lost in adult mammals. The logic behind the diversity of cardiac …

Cardiomyocyte (CM) proliferative potential varies considerably across species. While lower
vertebrates and neonatal mammals retain robust capacities for CM proliferation, adult …