User profiles for A. T. Papenfuss

Professor Tony Papenfuss

Theme Leader, Computational Biology, Walter and Eliza Hall Institute of Medical
Verified email at wehi.edu.au
Cited by 16029

The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer

…, JAM Graves, GM Woods, GJ Hannon, AT Papenfuss - Science, 2010 - science.org
… tumors at microsatellite and major histocompatibility complex loci (6). We genotyped at 14
… except for one single-nucleotide polymorphism at position 15,711, which supported the idea …

Regulation of apicomplexan actin-based motility

J Baum, AT Papenfuss, B Baum, TP Speed… - Nature Reviews …, 2006 - nature.com
At the centre of the molecular motor that underlies this unique mode of locomotion are
short, highly dynamic actin filaments. Recent molecular work, along with the availability of …

[HTML][HTML] How the evolution of multicellularity set the stage for cancer

AS Trigos, RB Pearson, AT Papenfuss… - British journal of …, 2018 - nature.com
… Mounting molecular evidence suggests altered interactions at the interface between unicellular
… Further gains could come from identifying genes at the interface between unicellular and …

Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences

…, RD Miller, RD Nicholls, M Oda, AT Papenfuss… - Nature, 2007 - nature.com
… genomes can be subdivided (at a resolution of 500 kb) into 510 collinear segments with an
N50 length (size x such that 50% of the assembly is in units of length at least x) of 19.7 Mb, …

A newly discovered protein export machine in malaria parasites

…, JA Boddey, M Rug, BJ Smith, AT Papenfuss… - Nature, 2009 - nature.com
… However, the conserved use of hexameric ring-forming AAA+ ATPases in many of these
systems, including the PTEX apparatus we describe here, hints at an ancient origin of this key …

BET inhibitor resistance emerges from leukaemia stem cells

…, SJ Dawson, BJP Huntly, RK Prinjha, AT Papenfuss… - Nature, 2015 - nature.com
… 3f), but β-catenin is now bound at these sites and able to sustain the expression of Myc (Fig. …
at Myc, we find that in the resistant cells, chromatin occupancy of β-catenin increases at the …

Taurine deficiency as a driver of aging

…, M Picard, S Gupta, V Velagapudi, AT Papenfuss… - Science, 2023 - science.org
… control solution or taurine at 1000 mg per kg body weight (T1000), once daily at 10:00 am, to
… The median life-span increase was 10 to 12%, and life expectancy at 28 months increased …

A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast

…, S Wilcox, GB Mann, kConFab, AT Papenfuss… - The EMBO …, 2021 - embopress.org
To examine global changes in breast heterogeneity across different states, we determined
the single‐cell transcriptomes of > 340,000 cells encompassing normal breast, preneoplastic …

[HTML][HTML] Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer

…, G Smith, K Hall, SMJ Searle, NP Carter, AT Papenfuss… - Cell, 2012 - cell.com
The Tasmanian devil (Sarcophilus harrisii), the largest marsupial carnivore, is endangered
due to a transmissible facial cancer spread by direct transfer of living cancer cells through …

UV-associated mutations underlie the etiology of MCV-negative Merkel cell carcinomas

…, RW Johnstone, SB Fox, GA McArthur, AT Papenfuss… - Cancer research, 2015 - AACR
… For archival FFPE samples, a modified protocol was used where tissue was digested in
Buffer ATL (Qiagen) containing proteinase K at 56C for 3 days with daily proteinase K …