User profiles for A. T. Papenfuss
Professor Tony PapenfussTheme Leader, Computational Biology, Walter and Eliza Hall Institute of Medical Verified email at wehi.edu.au Cited by 16029 |
The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer
… tumors at microsatellite and major histocompatibility complex loci (6). We genotyped at 14
… except for one single-nucleotide polymorphism at position 15,711, which supported the idea …
… except for one single-nucleotide polymorphism at position 15,711, which supported the idea …
Regulation of apicomplexan actin-based motility
… At the centre of the molecular motor that underlies this unique mode of locomotion are
short, highly dynamic actin filaments. Recent molecular work, along with the availability of …
short, highly dynamic actin filaments. Recent molecular work, along with the availability of …
[HTML][HTML] How the evolution of multicellularity set the stage for cancer
… Mounting molecular evidence suggests altered interactions at the interface between unicellular
… Further gains could come from identifying genes at the interface between unicellular and …
… Further gains could come from identifying genes at the interface between unicellular and …
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
… genomes can be subdivided (at a resolution of 500 kb) into 510 collinear segments with an
N50 length (size x such that 50% of the assembly is in units of length at least x) of 19.7 Mb, …
N50 length (size x such that 50% of the assembly is in units of length at least x) of 19.7 Mb, …
A newly discovered protein export machine in malaria parasites
… However, the conserved use of hexameric ring-forming AAA+ ATPases in many of these
systems, including the PTEX apparatus we describe here, hints at an ancient origin of this key …
systems, including the PTEX apparatus we describe here, hints at an ancient origin of this key …
BET inhibitor resistance emerges from leukaemia stem cells
… 3f), but β-catenin is now bound at these sites and able to sustain the expression of Myc (Fig. …
at Myc, we find that in the resistant cells, chromatin occupancy of β-catenin increases at the …
at Myc, we find that in the resistant cells, chromatin occupancy of β-catenin increases at the …
Taurine deficiency as a driver of aging
… control solution or taurine at 1000 mg per kg body weight (T1000), once daily at 10:00 am, to
… The median life-span increase was 10 to 12%, and life expectancy at 28 months increased …
… The median life-span increase was 10 to 12%, and life expectancy at 28 months increased …
A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast
…, S Wilcox, GB Mann, kConFab, AT Papenfuss… - The EMBO …, 2021 - embopress.org
To examine global changes in breast heterogeneity across different states, we determined
the single‐cell transcriptomes of > 340,000 cells encompassing normal breast, preneoplastic …
the single‐cell transcriptomes of > 340,000 cells encompassing normal breast, preneoplastic …
[HTML][HTML] Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer
…, G Smith, K Hall, SMJ Searle, NP Carter, AT Papenfuss… - Cell, 2012 - cell.com
The Tasmanian devil (Sarcophilus harrisii), the largest marsupial carnivore, is endangered
due to a transmissible facial cancer spread by direct transfer of living cancer cells through …
due to a transmissible facial cancer spread by direct transfer of living cancer cells through …
UV-associated mutations underlie the etiology of MCV-negative Merkel cell carcinomas
… For archival FFPE samples, a modified protocol was used where tissue was digested in
Buffer ATL (Qiagen) containing proteinase K at 56C for 3 days with daily proteinase K …
Buffer ATL (Qiagen) containing proteinase K at 56C for 3 days with daily proteinase K …