Novel strategies for the discovery of plant-derived anticancer agents

…, HA Navarro, RA Kramer, AT Menendez… - Pure and Applied …, 1999 - degruyter.com
… regions of the earth, and are being destroyed at an alarming rate [12]. In our study, priority is
given to species endemic to a particular country, and up to four anatomical parts of each plant …

Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: a novel and potent family of antitumor antibiotics

LM Hinman, PR Hamann, R Wallace, AT Menendez… - Cancer research, 1993 - AACR
… The MoAb was iodinated at pH 7.4 in phosphate buffer at a protein concentration of 1.25
mg/ml. using 5 mCi of Bolton-Hunter reagent for each 2.5 mg of protein iodinated. The labeled …

Synthesis and biological evaluation of analogues of cryptolepine, an alkaloid isolated from the Suriname rainforest

…, C Raventos-Suarez, AT Menendez… - Journal of natural …, 1999 - ACS Publications
… KOH under argon, 10,11 and decarboxylated by heating at 300 C to yield quindoline (4) in
at 110 C for 4 h gave the iodide salt (5), 10 while treatment with methyl triflate in toluene at

Scleritodermin A, a Cytotoxic Cyclic Peptide from the Lithistid Sponge Scleritoderma nodosum

…, M Bifano, AT Menendez… - Journal of natural …, 2004 - ACS Publications
… For instance, a proton singlet at δ 7.71 with a GHMQC correlation to a carbon signal at δ
119.0 is characteristic of a thiazole rather than an oxazole ring. The proposed structure of ACT …

An anti-MUC1 antibody− calicheamicin conjugate for treatment of solid tumors. choice of linker and overcoming drug resistance

…, C Lin, D Lindh, AT Menendez… - Bioconjugate …, 2005 - ACS Publications
… ovarian line at the maximum tolerated dose and also at 50% of … carbohydrate conjugate
caused more deaths at the 300 μg/kg … at the 150 μg/kg dose, and was somewhat less effective at

[HTML][HTML] Gene expression profiling of intestinal regeneration in the sea cucumber

…, EC Suárez-Castillo, K Tossas, AT Méndez-Merced… - BMC genomics, 2009 - Springer
… To do this, we used the expression profile at 7-dpe as reference (up-regulated genes at
We focused on contigs that showed over-expression at 3- and 7-dpe that were composed by at

Study of the effects of salicylic acid on soybean mitochondrial lipids and respiratory properties using the alternative oxidase as a stress‐reporter protein

AR Matos, AT Mendes, P Scotti‐Campos… - Physiologia …, 2009 - Wiley Online Library
… % (v/v) and centrifuged at 14000 g for 5 min at 4 C. The supernatants were reacted with TBA
solution at 95 C for 25 min. After centrifugation at 14000 g for 10 min at 4 C, absorbance at

Identification of Hox Gene Sequences in the Sea Cucumber Holothuria glaberrima Selenka (Holothuroidea: Echinodermata)

AT Méndez, JL Roig-López, P Santiago, C Santiago… - Marine …, 2000 - Springer
… Sequence analyses suggest that the holothuroid cluster has at least three genes of the
anterior, one of the medial, and five of the posterior groups. This is the first evidence of five …

Cytotoxic Constituents of the Roots of Ekmanianthe longiflora

…, CR Fairchild, KE Lane, AT Menendez… - Journal of natural …, 2000 - ACS Publications
at 247 and 287 nm). The HREIMS of 1 revealed a [M] + peak at m/z 246.1258 that corresponded
to a molecular formula of C 15 H 18 O 3 . The base peak at m/z 105 and a fragment at m/…

[HTML][HTML] Voluntary running in young adult mice reduces anxiety-like behavior and increases the accumulation of bioactive lipids in the cerebral cortex

…, JG Vélez-Bartolomei, AT Méndez-Merced… - PLoS …, 2013 - journals.plos.org
Combinatorial therapies using voluntary exercise and diet supplementation with polyunsaturated
fatty acids have synergistic effects benefiting brain function and behavior. Here, we …