User profiles for A. P. Klein
Alison P. KleinJohns Hopkins University Verified email at jhmi.edu Cited by 39261 |
Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors
AP Klein - Nature reviews Gastroenterology & hepatology, 2021 - nature.com
Pancreatic cancer is a leading cause of cancer death worldwide and its global burden has
more than doubled over the past 25 years. The highest incidence regions for pancreatic …
more than doubled over the past 25 years. The highest incidence regions for pancreatic …
Recent progress in pancreatic cancer
Answer questions and earn CME/CNE Pancreatic cancer is currently one of the deadliest of
the solid malignancies. However, surgery to resect neoplasms of the pancreas is safer and …
the solid malignancies. However, surgery to resect neoplasms of the pancreas is safer and …
Update on familial pancreatic cancer
Although some of the aggregation of pancreatic cancer in families is due to chance, and some
to shared environmental exposures such as cigarette smoking, much of this aggregation …
to shared environmental exposures such as cigarette smoking, much of this aggregation …
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
There are currently few therapeutic options for patients with pancreatic cancer, and new
insights into the pathogenesis of this lethal disease are urgently needed. Toward this end, we …
insights into the pathogenesis of this lethal disease are urgently needed. Toward this end, we …
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
Although many human cancers such as melanoma express tumor antigens recognized by T
cells, host immune responses often fail to control tumor growth for as yet unexplained …
cells, host immune responses often fail to control tumor growth for as yet unexplained …
Detection and localization of surgically resectable cancers with a multi-analyte blood test
Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can
detect eight common cancer types through assessment of the levels of circulating proteins and …
detect eight common cancer types through assessment of the levels of circulating proteins and …
Altered Telomeres in Tumors with ATRX and DAXX Mutations
The proteins encoded by ATRX and DAXX participate in chromatin remodeling at telomeres
and other genomic sites. Because inactivating mutations of these genes are common in …
and other genomic sites. Because inactivating mutations of these genes are common in …
[HTML][HTML] DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
…, JR Eshleman, M Raben, AP Klein… - Journal of clinical …, 2009 - ncbi.nlm.nih.gov
Purpose Contrary to the extensive data accumulated regarding pancreatic carcinogenesis,
the clinical and molecular features characteristic of advanced stage (stage III and IV) disease …
the clinical and molecular features characteristic of advanced stage (stage III and IV) disease …
Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene
Through complete sequencing of the protein-coding genes in a patient with familial pancreatic
cancer, we identified a germline, truncating mutation in PALB2 that appeared responsible …
cancer, we identified a germline, truncating mutation in PALB2 that appeared responsible …
Prevalence of unsuspected pancreatic cysts on MDCT
TA Laffan, KM Horton, AP Klein… - American Journal of …, 2008 - Am Roentgen Ray Soc
OBJECTIVE. Current generation MDCT technology facilitates identification of small, nonenhancing
lesions in the pancreas. The objective of this study was to determine the prevalence …
lesions in the pancreas. The objective of this study was to determine the prevalence …