User profiles for A. P. Klein

Alison P. Klein

Johns Hopkins University
Verified email at jhmi.edu
Cited by 39261

Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors

AP Klein - Nature reviews Gastroenterology & hepatology, 2021 - nature.com
Pancreatic cancer is a leading cause of cancer death worldwide and its global burden has
more than doubled over the past 25 years. The highest incidence regions for pancreatic …

Recent progress in pancreatic cancer

…, JM Herman, DA Laheru, AP Klein… - CA: a cancer journal …, 2013 - Wiley Online Library
Answer questions and earn CME/CNE Pancreatic cancer is currently one of the deadliest of
the solid malignancies. However, surgery to resect neoplasms of the pancreas is safer and …

Update on familial pancreatic cancer

…, M Goggins, R Schulick, AP Klein - Advances in …, 2010 - advancessurgery.com
Although some of the aggregation of pancreatic cancer in families is due to chance, and some
to shared environmental exposures such as cigarette smoking, much of this aggregation …

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

…, J Hartigan, DR Smith, M Hidalgo, SD Leach, AP Klein… - science, 2008 - science.org
There are currently few therapeutic options for patients with pancreatic cancer, and new
insights into the pathogenesis of this lethal disease are urgently needed. Toward this end, we …

Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape

…, R Sharma, TL McMiller, S Chen, AP Klein… - Science translational …, 2012 - science.org
Although many human cancers such as melanoma express tumor antigens recognized by T
cells, host immune responses often fail to control tumor growth for as yet unexplained …

Detection and localization of surgically resectable cancers with a multi-analyte blood test

…, M Dal Molin, TL Wang, R Roden, AP Klein… - Science, 2018 - science.org
Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can
detect eight common cancer types through assessment of the levels of circulating proteins and …

Altered Telomeres in Tumors with ATRX and DAXX Mutations

CM Heaphy, RF De Wilde, Y Jiao, AP Klein, BH Edil… - Science, 2011 - science.org
The proteins encoded by ATRX and DAXX participate in chromatin remodeling at telomeres
and other genomic sites. Because inactivating mutations of these genes are common in …

[HTML][HTML] DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer

…, JR Eshleman, M Raben, AP Klein… - Journal of clinical …, 2009 - ncbi.nlm.nih.gov
Purpose Contrary to the extensive data accumulated regarding pancreatic carcinogenesis,
the clinical and molecular features characteristic of advanced stage (stage III and IV) disease …

Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

…, B Vogelstein, JR Eshleman, M Goggins, AP Klein - Science, 2009 - science.org
Through complete sequencing of the protein-coding genes in a patient with familial pancreatic
cancer, we identified a germline, truncating mutation in PALB2 that appeared responsible …

Prevalence of unsuspected pancreatic cysts on MDCT

TA Laffan, KM Horton, AP Klein… - American Journal of …, 2008 - Am Roentgen Ray Soc
OBJECTIVE. Current generation MDCT technology facilitates identification of small, nonenhancing
lesions in the pancreas. The objective of this study was to determine the prevalence …