User profiles for A. P. Bird
 | Adrian BirdProfessor of Genetics, University of Edinburgh Verified email at ed.ac.uk Cited by 106070 |
[HTML][HTML] Methylation-induced repression—belts, braces, and chromatin
AP Bird, AP Wolffe - Cell, 1999 - cell.com
). It may also contribute to immobilization of mammalian transposons, suppression of
transcriptional noise, and the control of tissue-specific gene expression, but decisive evidence on …
transcriptional noise, and the control of tissue-specific gene expression, but decisive evidence on …
CpG-rich islands and the function of DNA methylation
AP Bird - Nature, 1986 - nature.com
It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in
which CpG is abundant and non-methylated. Highly tissue-specific genes, though, usually …
which CpG is abundant and non-methylated. Highly tissue-specific genes, though, usually …
Genomic DNA methylation: the mark and its mediators
Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in
the mammalian genome and is essential for embryonic viability. With several of the key …
the mammalian genome and is essential for embryonic viability. With several of the key …
DNA methylation and the frequency of CpG in animal DNA
AP Bird - Nucleic acids research, 1980 - academic.oup.com
An analysis of nearest neighbour dinucleotide frequencies and the level of DNA methylation
in animals strongly supports the suggestion that 5-methylcytosine (5mC) tends to mutate …
in animals strongly supports the suggestion that 5-methylcytosine (5mC) tends to mutate …
[HTML][HTML] The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation
DNA methylation plays an important role in mammalian development and correlates with
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG …
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG …
Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a
…, F Lyko, V Clark, AP Bird… - Proceedings of the …, 2000 - National Acad Sciences
… In the MvaI experiments (E and F), a small amount of labeling Ap, Tp, and Gp can also be
seen. This finding is attributable to background labeling at nicks in the DNA. The identities of …
seen. This finding is attributable to background labeling at nicks in the DNA. The identities of …
[HTML][HTML] CpG islands–'a rough guide'
RS Illingworth, AP Bird - FEBS letters, 2009 - Elsevier
Mammalian genomes are punctuated by DNA sequences containing an atypically high
frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation and …
frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation and …
Effects of DNA methylation on DNA-binding proteins and gene expression
PH Tate, AP Bird - Current opinion in genetics & development, 1993 - Elsevier
… This protein, whose amino acid sequence has been deduced from the cDNA, appears to
be considerably more abundant than MeCPl, and is able to bind to DNA containing a single …
be considerably more abundant than MeCPl, and is able to bind to DNA containing a single …
CpG islands as gene markers in the vertebrate nucleus
AP Bird - Trends in Genetics, 1987 - cell.com
Methylated and non. methylated DNA sequences coexist in many animal gems. In vertebrates
most of the genome is methylated, and non. methylated sequences are reduced to short" …
most of the genome is methylated, and non. methylated sequences are reduced to short" …
Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs
… islands that are found associated with many genes (Bird, 1986; Gardiner-Garden and
Frommer, … was designed to generate probes in which one strand was substituted with [a”*P]dGTP, …
Frommer, … was designed to generate probes in which one strand was substituted with [a”*P]dGTP, …