The face of evolutionary biology is changing: from reconstructing and analysing the past to
predicting future evolutionary processes. Recent developments include prediction of …

Genetic regulatory networks enable cells to respond to changes in internal and external
conditions by dynamically coordinating their gene expression profiles. Our ability to make …

T and B cell repertoires are collections of lymphocytes, each characterized by its antigen-specific
receptor. We review here classical technologies and analysis strategies developed to …

Flocking is a typical example of emergent collective behavior, where interactions between
individuals produce collective patterns on the large scale. Here we show how a quantitative …

Recognition of pathogens relies on families of proteins showing great diversity. Here we
construct maximum entropy models of the sequence repertoire, building on recent experiments …

Cancer immunoediting 1 is a hallmark of cancer 2 that predicts that lymphocytes kill more
immunogenic cancer cells to cause less immunogenic clones to dominate a population. …

… The work of AM was supported in part by the NSF Physics of Living Systems program (PHY-1022140).
CGC thanks the Institute for Advanced Study for hospitality during the …

An exact steady-state solution of the stochastic equations governing the behavior of a gene
regulated by a self-generated proteomic atmosphere is presented. The solutions depend on …

Flocks of birds exhibit a remarkable degree of coordination and collective response. It is not
just that thousands of individuals fly, on average, in the same direction and at the same …

High-throughput immune repertoire sequencing is promising to lead to new statistical diagnostic
tools for medicine and biology. Successful implementations of these methods require a …