Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring

…, M Malbari, CF Spinelli, S Kazancioglu, AM Runnels… - Nature medicine, 2020 - nature.com
In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free
DNA (cfDNA) shows promise in detecting cancer mutations, we found that the …

[HTML][HTML] Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression

R Kaletsky, V Yao, A Williams, AM Runnels… - PLoS …, 2018 - journals.plos.org
The biology and behavior of adults differ substantially from those of developing animals, and
cell-specific information is critical for deciphering the biology of multicellular animals. Thus, …

Mating and male pheromone kill Caenorhabditis males through distinct mechanisms

C Shi, AM Runnels, CT Murphy - elife, 2017 - elifesciences.org
10.7554/eLife.23493.001 Differences in longevity between sexes is a mysterious yet
general phenomenon across great evolutionary distances. To test the roles of responses to …

Remission of high blood pressure reverses arterial potassium channel alterations.

NJ Rusch, AM Runnells - Hypertension, 1994 - Am Heart Assoc
Rat arterial muscle cells show an elevated Ca(2+)-dependent K+ efflux during the established
phase of hypertension. This association of enhanced K+ efflux with high arterial pressure …

Mating-induced male death and pheromone Toxin-regulated androstasis

C Shi, AM Runnels, CT Murphy - bioRxiv, 2015 - biorxiv.org
How mating affects male lifespan is poorly understood. Using single worm lifespan assays,
we discovered that males live significantly shorter after mating in both androdioecious (male …

Development of resistance with host age to adhesion of K99+ Escherichia coli to isolated intestinal epithelial cells

PL Runnels, HW Moon, RA Schneider - Infection and Immunity, 1980 - Am Soc Microbiol
RUNNELS,* HARLEY W. MOON, AND ROBERT A. SCHNEIDER National Animal
Disease Center, United States Department ofAgriculture, Science and Education …

Capsule reduces adherence of enterotoxigenic Escherichia coli to isolated intestinal epithelial cells of pigs

PL Runnels, HW Moon - Infection and immunity, 1984 - Am Soc Microbiol
Previous reports have demonstrated that heat-stable (A-type) capsule on piliated enterotoxigenic
Escherichia coli enhances colonization of enterotoxigenic E. coli in the small intestine …

F41 pili as protective antigens of enterotoxigenic Escherichia coli that produce F41, K99, or both pilus antigens

PL Runnels, SL Moseley, HW Moon - Infection and immunity, 1987 - Am Soc Microbiol
Pigs suckling dams that have been vaccinated with pilus antigen are protected against
challenge with enterotoxigenic Escherichia coli (ETEC) strains that express the same pilus …

Adult-specific transcriptional changes of mating and aging in the major tissues of C. elegans

AM Runnels - 2018 - dataspace.princeton.edu
Caenorhabditis elegans is an excellent model organism for aging research. Major questions
in aging research include finding phenomena that accelerate the aging process and …

Vaccination of piglets up to 1 week of age with a single-dose Mycoplasma hyopneumoniae vaccine induces protective immunity within 2 weeks against virulent …

…, L Van Brussel, G Saunders, P Runnels… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
Enzootic pneumonia, resulting from infection with Mycoplasma hyopneumoniae , is of
considerable economic importance to the pig industry and normally is controlled through active …