[HTML][HTML] Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population
Cognitive impairment is common among individuals diagnosed with autism spectrum
disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). It has been suggested that …
disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). It has been suggested that …
[HTML][HTML] Epidemiology and heritability of major depressive disorder, stratified by age of onset, sex, and illness course in Generation Scotland: Scottish Family Health …
AM Fernandez-Pujals, MJ Adams, P Thomson… - PloS one, 2015 - journals.plos.org
The heritability of Major Depressive Disorder (MDD) has been estimated at 37% based largely
on twin studies that rely on contested assumptions. More recently, the heritability of MDD …
on twin studies that rely on contested assumptions. More recently, the heritability of MDD …
[HTML][HTML] Genetic and environmental risk for chronic pain and the contribution of risk variants for major depressive disorder: a family-based mixed-model analysis
…, SP Hagenaars, G Davies, AM Fernandez-Pujals… - PLoS …, 2016 - journals.plos.org
Background Chronic pain is highly prevalent and a significant source of disability, yet its
genetic and environmental risk factors are poorly understood. Its relationship with major …
genetic and environmental risk factors are poorly understood. Its relationship with major …
[HTML][HTML] Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data
Major depressive disorder (MDD) and Alzheimer’s disease (AD) are both common in older
age and frequently co-occur. Numerous phenotypic studies based on clinical diagnoses …
age and frequently co-occur. Numerous phenotypic studies based on clinical diagnoses …
Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population‐based cohort
Alcohol dependence is frequently co‐morbid with cognitive impairment. The relationship
between these traits is complex as cognitive dysfunction may arise as a consequence of heavy …
between these traits is complex as cognitive dysfunction may arise as a consequence of heavy …
[HTML][HTML] A combined pathway and regional heritability analysis indicates NETRIN1 pathway is associated with major depressive disorder
Background Genome-wide association studies (GWASs) of major depressive disorder (MDD)
have identified few significant associations. Testing the aggregation of genetic variants, in …
have identified few significant associations. Testing the aggregation of genetic variants, in …
[HTML][HTML] Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression
Background Both genetic and environmental factors contribute to risk of depression, but
estimates of their relative contributions are limited. Commonalities between clinically-assessed …
estimates of their relative contributions are limited. Commonalities between clinically-assessed …
[HTML][HTML] Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts
Major depressive disorder (MDD) is known for its substantial clinical and suspected causal
heterogeneity. It is characterized by low mood, psychomotor slowing and increased levels of …
heterogeneity. It is characterized by low mood, psychomotor slowing and increased levels of …
[HTML][HTML] Do regional brain volumes and major depressive disorder share genetic architecture? A study of Generation Scotland (n= 19 762), UK Biobank (n= 24 048) …
…, J Gibson, G Davies, AM Fernandez-Pujals… - Translational …, 2017 - nature.com
Major depressive disorder (MDD) is a heritable and highly debilitating condition. It is commonly
associated with subcortical volumetric abnormalities, the most replicated of these being …
associated with subcortical volumetric abnormalities, the most replicated of these being …
[HTML][HTML] Major depressive disorder and current psychological distress moderate the effect of polygenic risk for obesity on body mass index
Major depressive disorder (MDD) and obesity are frequently co-morbid and this correlation
is partly due to genetic factors. Although specific genetic risk variants are associated with …
is partly due to genetic factors. Although specific genetic risk variants are associated with …