An upstream protein-coding region in enteroviruses modulates virus infection in gut epithelial cells

V Lulla, AM Dinan, M Hosmillo, Y Chaudhry… - Nature …, 2019 - nature.com
Enteroviruses comprise a large group of mammalian pathogens that includes poliovirus.
Pathology in humans ranges from sub-clinical to acute flaccid paralysis, myocarditis and …

Translation initiation of leaderless and polycistronic transcripts in mammalian mitochondria

…, A Khawaja, SF Pearce, AM Dinan… - Nucleic acids …, 2023 - academic.oup.com
The synthesis of mitochondrial OXPHOS complexes is central to cellular metabolism, yet many
molecular details of mitochondrial translation remain elusive. It has been commonly held …

[HTML][HTML] Functional characterization of the Mycobacterium abscessus genome coupled with condition specific transcriptomics reveals conserved molecular strategies …

AA Miranda-CasoLuengo, PM Staunton, AM Dinan… - BMC genomics, 2016 - Springer
Background Mycobacterium abscessus subsp. abscessus (MAB) is a highly drug resistant
mycobacterium and the most common respiratory pathogen among the rapidly growing non-…

[PDF][PDF] Hybrid gene origination creates human-virus chimeric proteins during infection

…, M Chang, Y Fstkchyan, S Clohisey, AM Dinan… - Cell, 2020 - cell.com
RNA viruses are a major human health threat. The life cycles of many highly pathogenic RNA
viruses like influenza A virus (IAV) and Lassa virus depends on host mRNA, because viral …

A case for a negative-strand coding sequence in a group of positive-sense RNA viruses

AM Dinan, NI Lukhovitskaya, I Olendraite… - Virus …, 2020 - academic.oup.com
Positive-sense single-stranded RNA viruses form the largest and most diverse group of
eukaryote-infecting viruses. Their genomes comprise one or more segments of coding-sense …

Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression

GM Cook, K Brown, P Shang, Y Li, L Soday, AM Dinan… - Elife, 2022 - elifesciences.org
The arterivirus porcine reproductive and respiratory syndrome virus (PRRSV) causes
significant economic losses to the swine industry worldwide. Here we apply ribosome profiling (…

C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis

S Gopalakrishna, SF Pearce, AM Dinan… - Nucleic acids …, 2019 - academic.oup.com
In all biological systems, RNAs are associated with RNA-binding proteins (RBPs), forming
complexes that control gene regulatory mechanisms, from RNA synthesis to decay. In …

Comparative analysis of gene expression in virulent and attenuated strains of infectious bronchitis virus at subcodon resolution

AM Dinan, S Keep, E Bickerton, P Britton… - Journal of …, 2019 - Am Soc Microbiol
Like all coronaviruses, avian infectious bronchitis virus (IBV) possesses a long, single-stranded,
positive-sense RNA genome (∼27 kb) and has a complex replication strategy that …

Transcriptional and translational landscape of equine torovirus

H Stewart, K Brown, AM Dinan, N Irigoyen… - Journal of …, 2018 - Am Soc Microbiol
The genus Torovirus (subfamily Torovirinae , family Coronaviridae , order Nidovirales )
encompasses a range of species that infect domestic ungulates, including cattle, sheep, goats, …

Relaxed selection drives a noisy noncoding transcriptome in members of the Mycobacterium tuberculosis complex

AM Dinan, P Tong, AJ Lohan, KM Conlon… - MBio, 2014 - Am Soc Microbiol
Related species are often used to understand the molecular underpinning of virulence
through examination of a shared set of biological features attributable to a core genome of …