Glycogen is the storage form of carbohydrate for virtually every organism from yeast to
primates. Most mammalian tissues store glucose as glycogen, with the major depots located in …

CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in
Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of …

Purpose Several professional societies have published guidelines for the clinical interpretation
of somatic variants, which specifically address diagnostic, prognostic, and therapeutic …

Purpose Following automated variant calling, manual review of aligned read sequences is
required to identify a high-quality list of somatic variants. Despite widespread use in …

CIViC (Clinical Interpretation of Variants in Cancer; civicdb.org) is a crowd-sourced, public
domain knowledgebase composed of literature-derived evidence characterizing the clinical …

This paper investigates whether unexpected shocks in terms of road injuries ‘cause’ a
permanent change in disposable income, earnings, employment, and public transfer income. We …

Manually curated variant knowledgebases and their associated knowledge models are
serving an increasingly important role in distributing and interpreting variants in cancer. These …

Background Precision oncology involves analysis of individual cancer samples to understand
the genes and pathways involved in the development and progression of a cancer. To …

Early biochemical analyses of metabolic pathways assumed that the free diffusion of substrates
and enzymes in an evenly mixed cellular space provided the interactions that enabled …

Von Hippel‐Lindau (VHL) disease is a hereditary cancer syndrome where individuals are
predisposed to tumor development in the brain, adrenal gland, kidney, and other organs. It is …