La presente obra es el fruto por parte de los autores, de más de 25 años de docencia en
Bioestadística en la Facultad de Medicina de Granada, además de diversos cursos impartidos …

Modern humans inhabit a variety of environments and are exposed to a plethora of selective
pressures, leading to multiple genetic adaptations to local environmental conditions. These …

Most human polymorphisms are neutral or slightly deleterious, but some genetic variation is
advantageous and maintained in populations by balancing selection. Considered a rarity …

Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes)
and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and …

We present a DNA library preparation method that has allowed us to reconstruct a high-coverage
(30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality …

Most great ape genetic variation remains uncharacterized 1 , 2 ; however, its study is critical
for understanding population history 3 , 4 , 5 , 6 , recombination 7 , selection 8 and …

To date, the only Neandertal genome that has been sequenced to high quality is from an
individual found in Southern Siberia. We sequenced the genome of a female Neandertal from ~…

It has been shown that Neanderthals contributed genetically to modern humans outside
Africa 47,000–65,000 years ago. Here we analyse the genomes of a Neanderthal and a …

Balancing selection is potentially an important biological force for maintaining advantageous
genetic diversity in populations, including variation that is responsible for long-term …

Our closest living relatives, chimpanzees and bonobos, have a complex demographic
history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and …