CTLA-4 is one of the most important negative regulators of the T cell immune response.
However, the subcellular distribution of CTLA-4 is unusual for a receptor that interacts with cell …

… Since any of the four interaction sites can support CME (Willox and Royle, 2012), then this
… lacks all four interaction sites (ΔNTD or CDEG (Willox and Royle, 2012)) is unable to support …

A long-standing paradigm in cell biology is the shutdown of endocytosis during mitosis.
There is consensus that transferrin uptake is inhibited after entry into prophase and that it …

In clathrin‐mediated membrane traffic, clathrin does not bind directly to cargo and instead
binds to adaptors that mediate this function. For endocytosis, the main adaptor is the adaptor …

At small synapses in the brain, clathrin-mediated endocytosis (CME) is the dominant mode
of synaptic vesicle retrieval following weak stimulation [1–4]. Clathrin cannot bind to …

Indigenous people living in the Circumpolar North rely, to varying degrees, on the natural
environment and the resources it provides for their lifestyle and livelihoods. As a consequence, …

We present a discrete analogue of the so-called symmetry reduced or `constrained' KP
hierarchy. As a result we obtain integrable discretisations, in both space and time, of some well-…

… Suicide rates for 15 to 24 year-old Alaska Native males is 14 times the national rate (Citation16)
and, in northwest Alaska, suicide is the leading cause of death for 15 to 18 year-old …

… at Anchorage September 8-9, 2011 for their feedback on an early draft of this paper, with
particular thanks to Terrence Kelly (University of Alaska at Anchorage) for his astute insights …

… Work from Northern Canadian communities and from Alaska have identified informal
interaction as a youth-identified coping mechanism and protective factor, both broadly and within …