Histone acetylation plays important roles in gene regulation, DNA replication, and the response
to DNA damage, and it is frequently deregulated in tumors. We postulated that tumor cell …

Background— The failing human heart is characterized by metabolic abnormalities, but
these defects remains incompletely understood. In animal models of heart failure there is a …

10.7554/eLife.11612.001 Macrophage activation/polarization to distinct functional states is
critically supported by metabolic shifts. How polarizing signals coordinate metabolic and …

The precise characterization of cortical connectivity is important for the understanding of
brain morphological and functional organization. Such connectivity is conveyed by specific …

A screening programme to detect preinvasive carcinoma of the cervix was started in British
Columbia in 1949. Since 1970 the number of women who have been screened at least once …

The desire to correct intensity nonuniformity in magnetic resonance images has led to the
proliferation of nonuniformity-correction (NUC) algorithms with different theoretical …

The antitumor agent lonidamine (LND; 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid)
is known to interfere with energy-yielding processes in cancer cells. However, the effect of …

Etomoxir (ETO) is a widely used small-molecule inhibitor of fatty acid oxidation (FAO) through
its irreversible inhibitory effects on the carnitine palmitoyl-transferase 1a (CPT1a). We used …

Canine hip dysplasia (CHD) is a developmental orthopaedic disease of the coxofemoral
joints with a multifactorial mode of inheritance. Multiple gene effects are influenced by …

Extract Degenerative lumbosacral stenosis (DLSS) is a common condition amongst active
large-breed dogs, and has a complex aetiopathogenesis. Diagnosis is hampered by subtle …