User profiles for A. J. Stonestrom

Aaron J Stonestrom

Memorial Sloan Kettering Cancer Center
Verified email at mskcc.org
Cited by 2231

[HTML][HTML] Transport capabilities of eleven gram-positive bacteria: comparative genomic analyses

…, C Tran, B Winnen, RN Hvorup, AJ Stonestrom… - … et Biophysica Acta (BBA …, 2007 - Elsevier
The genomes of eleven Gram-positive bacteria that are important for human health and the
food industry, nine low G+C lactic acid bacteria and two high G+C Gram-positive organisms, …

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

…, MI Lefterova, L Ying, AJ Stonestrom… - … and cellular biology, 2008 - Taylor & Francis
The histone H3 lysine 79 methyltransferase DOT1L/KMT4 can promote an oncogenic
pattern of gene expression through binding with several MLL fusion partners found in acute …

[HTML][HTML] Targeting mutations in cancer

MR Waarts, AJ Stonestrom, YC Park… - The Journal of clinical …, 2022 - Am Soc Clin Investig
Targeted therapies have come to play an increasingly important role in cancer therapy over
the past two decades. This success has been made possible in large part by technological …

Chemotherapy and COVID-19 outcomes in patients with cancer

J Jee, MB Foote, M Lumish, AJ Stonestrom… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Coronavirus-2019 (COVID-19) mortality is higher in patients with cancer than in
the general population, yet the cancer-associated risk factors for COVID-19 adverse …

MEN1 mutations mediate clinical resistance to menin inhibition

…, S Mowla, W Xiao, HA Gamlen, AJ Stonestrom… - Nature, 2023 - nature.com
Chromatin-binding proteins are critical regulators of cell state in haematopoiesis 1 , 2 . Acute
leukaemias driven by rearrangement of the mixed lineage leukaemia 1 gene (KMT2Ar) or …

[PDF][PDF] The BET protein BRD2 cooperates with CTCF to enforce transcriptional and architectural boundaries

…, CR Bartman, CR Edwards, AJ Stonestrom… - Molecular cell, 2017 - cell.com
Bromodomain and extraterminal motif (BET) proteins are pharmacologic targets for the treatment
of diverse diseases, yet the roles of individual BET family members remain unclear. We …

Functions of BET proteins in erythroid gene expression

AJ Stonestrom, SC Hsu, KS Jahn… - Blood, The Journal …, 2015 - ashpublications.org
Inhibitors of bromodomain and extraterminal motif proteins (BETs) are being evaluated for
the treatment of cancer and other diseases, yet much remains to be learned about how BET …

A hyperactive transcriptional state marks genome reactivation at the mitosis–G1 transition

…, P Huang, P Ginart, AJ Stonestrom… - Genes & …, 2016 - genesdev.cshlp.org
During mitosis, RNA polymerase II (Pol II) and many transcription factors dissociate from
chromatin, and transcription ceases globally. Transcription is known to restart in bulk by …

Plasma proteomics identifies a 'chemokine storm'in idiopathic multicentric Castleman disease

SK Pierson, AJ Stonestrom, D Shilling… - American journal of …, 2018 - Wiley Online Library
Human Herpesvirus‐8 (HHV‐8)‐negative/idiopathic multicentric Castleman disease (iMCD)
is a poorly understood disease involving polyclonal lymphoproliferation with dysmorphic …

Interaction between myelodysplasia-related gene mutations and ontogeny in acute myeloid leukemia

…, ME Arcila, AJ Stonestrom… - Blood …, 2023 - ashpublications.org
Accurate classification and risk stratification are critical for clinical decision making in patients
with acute myeloid leukemia (AML). In the newly proposed World Health Organization and …