Our understanding of bacterial pathogenesis is dominated by the cell biology of the host–pathogen
interaction. However, the majority of metabolites that are used in prokaryotic and …

Nitric oxide contributes to protection from tuberculosis. It is generally assumed that this
protection is due to direct inhibition of Mycobacterium tuberculosis growth, which prevents …

Shigella flexneri, the causative agent of shigellosis, is a gram-negative bacterial pathogen
that initiates infection by invading cells within the colonic epithelium. Contact with host cell …

Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease
in the United States. Chlamydia infections that ascend to the upper genital tract can persist, …

M. tuberculosis (Mtb) survives a hostile environment within the host that is shaped in part by
oxidative stress. The mechanisms used by Mtb to resist these stresses remain ill-defined …

Abstract Treatment of cells with brefeldin A (BFA) blocks secretory vesicle transport and
causes a collapse of the Golgi apparatus. To gain more insight into the cellular mechanisms …

Shigella flexneri uses its type III secretion apparatus (TTSA) to deliver invasins into human
cells. This TTSA possesses an external needle with IpaD at its tip. We now show that …

… We thank the Olive lab for helpful discussions. We apologize to all the investigators we
were … Olive AJ, Sassetti CM. 2018. Tolerating the unwelcome guest; how the host withstands …

… BCG conferred protection in the spleens but not the lungs of four additional lines (129,
CC019, CAST, and A/J). The remaining genotypes were not protected by vaccination in either …

Type III secretion (TTS) is an essential virulence function for Shigella flexneri that delivers
effector proteins that are responsible for bacterial invasion of intestinal epithelial cells. The …