The tumor suppressor gene p53 plays a major role in regulation of the mammalian cellular
stress response, in part through the transcriptional activation of genes involved in cell cycle …

The first identified Gadd45 gene, Gadd45a, encodes a ubiquitously expressed protein that
is often induced by DNA damage and other stress signals associated with growth arrest and …

The p38 proteins are an evolutionally conserved family of mitogen-activated protein kinases
(MAPK). Recent studies have led to progress in our understanding the roles of p38 MAPK in …

C: ell cycle checkpoints can enhance cell survival and liimit mutagenic events following
DNA damage. Primary murine fibroblasts became deficient in a Gl clheckpoint activated by …

Since 1990, the National Cancer Institute (NCI) has screened more than 60,000 compounds
against a panel of 60 human cancer cell lines. The 50-percent growth-inhibitory …

GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and
certain other stresses. Like another p53-regulated gene, p21 WAF1/CIP1 , whose product …

It has been convincingly demonstrated that genotoxic stresses cause the accumulation of the
tumor suppressor gene p53. One important consequence of increased p53 protein levels in …

In the present study, we report the characterization of the p53 tumor suppressor pathway in
the 60 cell lines of the National Cancer Institute (NCI) anticancer drug screen, as well as …

The signaling pathway from phosphoinositide 3-kinase to the protein kinase Akt controls
organismal life-span in invertebrates and cell survival and proliferation in mammals by …

… More than 20 different cDNA clones encoding DNA-damage-inducible transcripts in rodent
cells have recently been isolated by hybridization subtraction (AJ Fornace, Jr., I. Alamo, Jr., …