Candidate gene and genome-wide association studies (GWAS) have identified genetic variants
that modulate risk for human disease; many of these associations require further study to …

The promise of “personalized medicine” guided by an understanding of each individual's
genome has been fostered by increasingly powerful and economical methods to acquire …

Large-scale DNA databanks linked to electronic medical record (EMR) systems have been
proposed as an approach for rapidly generating large, diverse cohorts for discovery and …

We repurposed existing genotypes in DNA biobanks across the Electronic Medical Records
and Genomics network to perform a genome-wide association study for primary …

Human genomic sequencing has potential diagnostic, prognostic, and therapeutic value
across a wide breadth of clinical disciplines. One barrier to widespread adoption is the paucity …

Interindividual variation in response to metformin, first‐line therapy for type 2 diabetes, is
substantial. Given that transporters are determinants of metformin pharmacokinetics, we …

Routine integration of genotype data into drug decision making could improve patient safety,
particularly if many relevant genetic variants can be assayed simultaneously before …

Genetic association studies often examine features independently, potentially missing
subpopulations with multiple phenotypes that share a single cause. We describe an approach that …

Background— ECG QRS duration, a measure of cardiac intraventricular conduction, varies
≈2-fold in individuals without cardiac disease. Slow conduction may promote re-entrant …

Multidrug and toxin extrusion 2 (MATE2‐K (SLC47A2)), a polyspecific organic cation
exporter, facilitates the renal elimination of the antidiabetes drug metformin. In this study, we …